基因重组型人促白细胞生成素在儿童恶性肿瘤化疗中的应用观察  

OBSERVATION ON APPLICATION OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FOR CHILDREN WITH MALIGNANT TUMOR RECEIVING CHEMOTHERAPY

作　　者：刘壮[1] 林善修[1] 

机构地区：[1]广西医科大学一附院

出　　处：《白血病》1998年第2期81-83,共3页

摘　　要：采用基因重组型人促白细胞生成素（γＨｕＧＭ－ＣＳＦ）进行３４例儿童恶性肿瘤３８例次化疗后粒细胞缺乏症的应用观察，ＷＢＣ＜２．０×１０９／Ｌ或ＡＮＣ＜０．５×１０９／Ｌ时每日用γＨｕＧＭ－ＣＳＦ２μｇ／ｋｇ．ｄ～５μｇ／ｋｇ，连用２ｄ～５ｄ，取得显著效果，与对照组比较，ＷＢＣ≥４．０×１０９／Ｌ提前８．３ｄ（Ｐ＜０．０１），发热和口腔溃疡发生率分别减少３３％和２８％，存在时间分别缩短了２．９ｄ和３．６ｄ，输血及成分输血减少了２．４次。We used recombinant human granulocyte macrophage colony stimulating factor ( γHuGM CSF)to treat 34 cases (38 times) of children with granulocytopenia post chemotherapy of malignant tumor. In treatment course, they were given γHuGM CSF 2 5μg/kg. The recovery time for WBC(≥4.0×10 9/L) in experimental group was 8.3 days earlier than that in control group. In experimental group comparing with the control group, frequencies of fever and mouth ulcer were reduced to 33 percent and 28 percent, respeetively, their continuing times were 2.9 days and 3.6 days shorter, blood and component blood transfussions were 2.4 times decreased.

关 键 词：儿童 粒细胞缺乏症 药物疗法 恶性肿瘤 白血病 

分 类 号：R733.710.5[医药卫生—肿瘤]