人肝细胞癌及癌旁组织中p53蛋白和PCNA的表达  

p53 Protein and PCNA Expressions in Hepatocellular Carcinoma and Pericarcinoma Tissues

作　　者：邹伟[1] 张昭成[1] 牛兆山[1] 赵军[1] 

机构地区：[1]青岛医学院病理学教研室 [2]青岛市第八人民医院

出　　处：《实用癌症杂志》1998年第2期102-104,共3页The Practical Journal of Cancer

基　　金：山东省教委科研基金

摘　　要：应用免疫组化方法检测了７３例肝细胞癌及癌旁组织中ｐ５３蛋白的表达，７０例肝细胞癌及癌旁组织中ＰＣＮＡ的表达。结果ｐ５３蛋白、ＰＣＮＡ在肝细胞癌中阳性表达率显著高于癌旁组织，且与肝细胞癌分化程度密切相关。癌旁组织中，ｐ５３蛋白表达仅见于增生结节中，肝硬化组织均为阴性；增生结节中ＰＣＮＡ阳性表达显著高于肝硬化组织。提示ｐ５３基因突变是肝细胞癌的频发事件，在肝细胞癌的发生发展中起重要作用；增生结节细胞的增殖活性增强，是肝细胞癌的癌前病变。p53 protein expression in 73 cases of hepatocellular carcinoma (HCC) and PCNA expression in 70 cases of HCC and their pericarcinoma tissue were examined with LSAB immunohistochemical technique. The results showed that the expressions of p53 and PCNA in HCC were significantly higher than those in pericarcinoma tissue, and closely correlated with histological differenciation grade. In pericarcinoma tissues, p53 protein expression was detected only in liver hyperplastic nodule (LHN), but not in liver cirrhosis. PCNA positive grade in LHN was higher than that in liver cirrhosis. The results suggest that mutation of p53 gene is frequent and correlative with progression of HCC. An increased proliferating activity of LHN might be the preneoplastic event of HCC.

关 键 词：肝肿瘤 肝细胞癌 P53蛋白 增殖细胞核抗原 PCNA 

分 类 号：R735.7[医药卫生—肿瘤]