角膜缘干细胞移植和羊膜移植术治疗复发性翼状胬肉临床疗效比较  

Compare the effects of recurrent pterygium treated by limbal stem cell transplantation and amniotic membrane transplantation

作　　者：姜小芬 万水英 

机构地区：[1]新晃县人民医院眼科,湖南新晃县419200

出　　处：《中国实用眼科杂志》2009年第6期639-640,共2页Chinese Journal of Practical Ophthalmology

摘　　要：目的比较角膜缘干细胞移植术和羊膜移植术治疗复发性翼状胬肉的临床疗效。方法将66例（69只眼）患者随机分为两组，分别采用角膜缘干细胞移植术（33例34只眼）和羊膜移植术（33例35只眼）治疗，术后随访1～2年。结果角膜缘干细胞移植组1只眼复发，复发率为2．94％；羊膜移植组8只眼复发，复发率为22．9％，两组比较差异有统计学意义（X^2=4．389，P〈0．05）。角膜创面上皮平均愈合时间角膜缘干细胞移植为3-5（4．5±2．4）d，羊膜移植组为5-8（6．5±2．6）d，两组比较差异有统计学意义，（t=3-317，P〈0．05）。结论角膜缘干细胞移植术治疗复发性翼状胬肉复发率低，角膜创面修复快，是一种理想的手术方法，值得推广应用。Objective To compare the therapeutic effects of recurrent pterygium treated by limbal stern cell transplantation and amniotic membrane transplantation. Methods Sixty-six cases （69eyes） with recurrent pterygium were randomly divided into limbal stem cell autograft transplantation group （33cases, 34eyes ） and amniotic membrane transplantation group （33cases, 35eyes）. The post operative follow-up periods were 12 to 24 months. Results Recurrence of one eye was noted in limbal stem cell autografl transplantation group ,the recurrent rate was 2.94%, however recurrence of eight eyes were noted in amniotic membrane transplantation group, the recurrent rate was 22.9%. There was statistical significant difference between two groups （X^2=4.389, P 〈0.05 ）. The average epithelial recovering time of corneal wound was 4.5 days, and 6.5 days, respectively, the difference was statistical significant （ t =3.317, P 〈0.01 ）. Conclusion Limbal stem cells autograft transplantation can decrease the recurrent rate, improve epithelial recovering time of corneal wound, it is an ideal method for treating the recurrent pterygium and is worth to spreading.

关 键 词：复发性翼状胬肉 角膜缘干细胞 羊膜 移植术 

分 类 号：R777.33[医药卫生—眼科] R683.42[医药卫生—临床医学]