曲安奈德治疗视网膜分支静脉阻塞继发黄斑水肿的疗效评估  

Macular function by optical coherence tomography and multffocal electroretinogram in macular edema secondary to BRVO after intravitreal triamcinolone acetonide injection

作　　者：陈吉 姚进 蒋沁 袁南荣 

机构地区：[1]雨花台区妇幼保健所,南京210029

出　　处：《中国实用眼科杂志》2009年第6期662-664,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的应用光学相干断层扫描（optical coherence to mography，OCT）和多焦视网膜电流图（multifocal electmretinogram，mfERG），随访观察曲安奈德玻璃体腔注射治疗视网膜分支静脉阻塞继发黄斑水肿患者的疗效。方法对28例视网膜分支静脉阻塞继发黄斑水肿患者，于曲安奈德玻璃体腔注射前后进行视力及OCT、mfERG检查，对比分析视力与视网膜神经上皮层厚度及黄斑区视功能变化。结果：与治疗前相比，视力均有不同幅度的提高；视网膜神经上皮层厚度平均厚度明显降低；中心凹处（1环）P1波振幅密度增加，均与治疗前比较差异具有统计学意义（P〈0．05）。结论应用OCT、mfERG随访检查，可以对病情的发展进行有效的跟踪观察，为曲安奈德玻璃体腔注射治疗的疗效提供可靠的依据。Objective To observe the therapeutic efficacy of intravitreal injection of triamcinolone acetonide （IVTA） for macular edema secondary to BRVO determined by optic coherence tomography （OCT） and multifocal electroretinogram （mfERG）. Methods TA was injected intravitreally in 28 eyes of 28 patients with macular edema secondary to BRVO determined by OCT and mIERG. The change of visual acuity, the macular thickness measured by OCT and macular function by mfERG were recorded and analyzed. Results Visual acuity was improved significantly at the end of the follow up. The average macular thickness and the average P1 amplitude was improved after treatment, which had statistical significance （P 〈0.05 ）. Conclusion IVTA could alleviate the macular edema secondary to BRVO. OCT and mtERG were useful means to evaluate the macular changes before and after ITA for BRVO.

关 键 词：视网膜静脉阻塞 继发黄斑水肿 光学相干断层扫描 多焦视网膜电流图 曲安奈德 

分 类 号：R774.1[医药卫生—眼科] R619.6[医药卫生—临床医学]