IL-1α促进骨巨细胞瘤中破骨样细胞体外骨吸收研究  

IL-1α PROMOTES THE BONE RESORPTION INDUCED BY THE OSTEOCLASTLIKE CELL SEPARATED FROM THE GIANT CELL TUMOUR OF BONE

作　　者：赵宁侠[1] 于世凤[1] 庞淑珍[1] 

机构地区：[1]北京医科大学口腔医学院口腔病理研究室

出　　处：《北京医科大学学报》1998年第3期246-248,共3页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金

摘　　要：目的：比较骨巨细胞瘤中的多核巨细胞与破骨细胞骨吸收的功能特点。方法：体外分离骨巨细胞瘤中的多核巨细胞与骨片共同培养，观察ＩＬ１α（５０μｇ／Ｌ，１００μｇ／Ｌ）对多核巨细胞体外骨吸收的影响。结果：ＩＬ１α可使多核巨细胞骨吸收陷窝的数目和面积增加；其作用随剂量增加而增强；ＩＬ１α对多核巨细胞的促进作用具有长效性。结论：ＩＬ１α具有促进多核巨细胞体外骨吸收作用，说明多核巨细胞与破骨细胞在骨吸收功能方面有相似性。Objective: To compare the function of bone resorption by the multinucleated giant cell (MGC) separated from giant cell tumour(GCT) with the osteoclast. Methods: The multinucleated giant cells (MGC) were separated from giant cell tumour and cultured with bone slice. The effect of IL-1α(50 μg/L, 100　μg/L)on bone resorption by MGC was observed. Results: IL-1α enchanced the numbers and the area of bone resorption lacunae on bone slices and it was dosedepended. MGC could maintain the ability of bone resorption over a long period(1 month). Conclusion: IL-1α promotes bone resorption induced by MGC. The MGC does have the same function of bone resorption as the osteoclast.

关 键 词：骨肿瘤 骨巨细胞瘤 破骨细胞 骨质吸收 IL-1Α 

分 类 号：R738.1[医药卫生—肿瘤]