脑缺血再灌注TXA_2-PGI_2平衡障碍及光量子液疗的影响  

Effects of Ultraviolet Liquid Irradiation on the Imbalance of TXA 2 PGI 2 in Cerebral Ischemia Reperfusion

作　　者：阎福岭[1,2] 张丙谦[1,2] 连亚军[1,2] 方树友 能昌华[1,2] 许予明 

机构地区：[1]河南医科大学第一附属医院 [2]河南省医学情报研究所

出　　处：《中华物理医学杂志》1998年第2期93-95,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的观察丹参和光量子液疗对脑缺血再灌注损伤ＴＸＡ２－ＰＧＩ２平衡的作用，探讨脑缺血治疗机制。方法制作兔脑缺血再灌注模型，分成单纯液体组、光量子液疗组、丹参组、光量子化丹参组和假手术对照组，进行不同的处理。分别检测各组血与脑组织中血栓素Ｂ２（ＴＸＢ２）和６酮前列腺素Ｆ１α（６ｋｅｔｏＰＧＦ１α）含量，计算Ｔ／Ｐ比值。结果单纯液体组ＴＸＢ２和６ｋｅｔｏＰＧＦ１α较假手术组不同程度地增高，Ｔ／Ｐ比值升高；而光量子液疗组、丹参组和光量子化丹参组６ｋｅｔｏＰＧＦ１α较单纯液体组增高，ＴＸＢ２和Ｔ／Ｐ比值则较单纯液体组降低，以光量子化丹参组对指标的影响最大。结论脑缺血再灌注损伤出现明显的ＴＸＡ２－ＰＧＩ２平衡障碍，丹参和光量子液疗可增加ＰＧＩ２含量，减少ＴＸＡ２生成，降低Ｔ／Ｐ比值；调节ＴＸＡ２－ＰＧＩ２平衡可能是丹参和光量子液疗治疗脑缺血的机制，光量子液疗可协同丹参作用。Objective To observe the effects of Danshen and ultraviolet liquid irradiation (ULI) on the imbalance of TXA 2 PGI 2 in cerebral ischemia reperfusion models and explore their therapeutic mechanism on cerebral ischemia. Methods The models of cerebral ischemia reperfusion in the rabbits were made and divided into 4 groups in addition to sham operated control group, including simple solution group, ULI group, Danshen group and Danshen with ULI group. Then TXB 2, 6 keto PGF 1α and T/P ratio of the brain tissue and serum in each group were measured respectively. Results TXB 2, 6 keto PGF 1α and the ratio of T/P in simple solution group were much higher than in sham operate group. The levels of 6 keto PGF 1α were higher and the levels of TXB 2 and the ratio of T/P were much lower in groups of ULI, Danshen, Danshen with ULI than in simple solution group. Conclusion There is obvious disorder of TXA 2 PGI 2 balance in cerebral ischemia reperfusion models. Danshen and ULI can increase the contents of PGI 2, decrease the levels of TXA 2 and decline the ratio of T/P. It seems to be the therapeutic mechanism for Danshen and ULI to improve the balance of TXA 2 PGI 2. ULI can enhance the function of Danshen.

关 键 词：脑缺血 丹参 光量子疗法 再灌注损伤 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学] R277.733.1[医药卫生—临床医学]