利培酮治疗儿童精神疾病的临床初探  

A pilot study of risperidone in the treatment of psychiatric disorders in childhood

作　　者：陈一心[1] 罗硕军[1] 柯晓燕[1] 金利波[1] 焦公凯[1] 

机构地区：[1]南京医科大学脑科医院

出　　处：《临床精神医学杂志》1998年第3期145-147,共3页Journal of Clinical Psychiatry

摘　　要：对１６例儿童精神疾病患者给予利培酮治疗，以临床总体印象量表等评定疗效及药物不良反应。治疗结果显示：儿童精神分裂症１０例中有效７例，Ｔｏｕｒｅｔｔｅ综合征（ＴＳ）４例中有效３例，孤独症２例中有效１例，显效时间为２周，有效日剂量儿童精神分裂症和孤独症为２～３ｍｇ，ＴＳ为１～１．５ｍｇ。５６．３％的患儿出现药物副反应。提示利培酮对儿童精神分裂症、ＴＳ和孤独症部分症状有效。bjective:To study the efficacy and side effects of risperidone in the treatment of psychiatric disorders in childhood. Method:Sixteen child were treated with risperidone,dose 1-5mg daily for 2-8 weeks.The Clinical Global Impression Scale (CGI) and others were used to assess the efficacy and side effects. Results:7 of 10 childhood schizophrenia,3 of 4 Tourette syndrome and 1 of 2 autism patients showed improvement which was evident at 2 weeks.The optimal dosage for schizophrenia and autism ranged from 2-3 mg daily while that for Tourette syndrome was 1-15mg daily.563% of subjects showed significant side effects. Discussion:Risperidone is effective with child patients suffering from schizophrenia,Tourette syndrome and autism,especially for the positive symptoms.

关 键 词：利培酮 儿童精神分裂症 Tourete综合征 孤独症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]