壳聚糖的化学改性(Ⅰ)  

Chemical Modification of Chitosan(Ⅰ)

作　　者：赵旭升[1] 刘光华[1] 干建群[1] 

机构地区：[1]中国科学院广州化学研究所,广东广州510650

出　　处：《纤维素科学与技术》2009年第2期50-59,共10页Journal of Cellulose Science and Technology

基　　金：广东省自然科学基金(07006838);广州市天河区科技计划(074G028)资助项目

摘　　要：壳聚糖是一种带阳离子的天然活性多糖,在一定条件下可以发生降解反应,其降解产物具有比壳聚糖更优良的功能特性,广泛应用于医药、食品、农业及环保等领域。壳聚糖与醛、酮可发生Schiff反应生成相应的醛亚胺或酮亚胺化合物,后者在氢硼化物作用下加氢进一步转化为各种N-烷基类衍生物。文章概述了近年来壳聚糖化学改性方面取得的某些研究进展,主要包括糖类改性,三甲基化、N-琥珀酰化、硫醇化和叠氮化改性,环状糊精改性,冠醚改性,化学接枝改性等。Chitosan is a cationic polysaccharide that supports numerous living organisms and can be promptly depolymerized with better functional properties, leading to its extensive applications in pharmaceutics, food, agriculture and environmental protection. The Schiff reaction between chitosan and aldehydes or ketones yields the corresponding aldimines or ketimines, which are converted to N-alkyl derivatives upon hydrogenation with borohydride. The present paper outlined the recent advances in the chemical modification of chitosans with the emphasis on sugarmodified chitosan and trimethylated, N-succinylated, thiolated, and azidated chitosans, as well as cyclodextrin-linked chitosan, crown-ether-bound chitosan and chemical grafting of chitosan.

关 键 词：壳聚糖 化学改性 环状糊精 冠醚 药物释放 

分 类 号：O636.1[理学—高分子化学]