Effects of nitroquine on ultrastructures and cytochrome oxidase of exoerythrocytic Plasmodium yoeli in rat liver  

Effects of nitroquine on ultrastructures and cytochrome oxidase of exoerythrocytic Plasmodium yoelii in rat liver 1

作　　者：陈晓红[1] 胡友梅[1] 廖雅琴[1] 柯金星[1] 张文军[1] 

机构地区：[1]第三军医大学药理教研室

出　　处：《中国药理学报》1998年第4期390-393,共4页Acta Pharmacologica Sinica

摘　　要：ｆｅｃｔｓｏｆｎｉｔｒｏｑｕｉｎｅｏｎｕｌｔｒａｓｔｒｕｃｔｕｒｅｓａｎｄｃｙｔｏｃｈｒｏｍｅｏｘｉｄａｓｅｏｆｅｘｏｅｒｙｔｈｒｏｃｙｔｉｃＰｌａｓｍｏｄｉｕｍｙｏｅｌｉｉｎｒａｔｌｉｖｅｒ１ＣＨＥＮＸｉａｏＨｏｎｇ２，ＨＵＹｏｕＭｅｉ，ＬＩＡ...AIM: To study the effects of nitroquine acetate (NA) on the ultrastructures and cytochrome c oxidase(CCO) of exoerythrocytic forms (EEF) of Plasmodium yoelii . METHODS: Rats were inoculated with sporozoites directly into the liver. After 48 h rats were killed. Rat liver thin sections were incubated in histochemical reaction medium, then examined by transmission electron microscopy. NA (2 mg·kg -1 ) was fed to rats 3 5 h and 14 h before killing the rats. RESULTS: At 3 5 h, in the parasites there appeared swelling and proliferation of mitochondria, dilation of endoplasmic reticulum, and reduction of the electron density of parasites nuclei. The structures of the parasites disintegrated to form many autophagocytes 14 h after exposure to NA. The reaction products of CCO still existed until 14 h after using NA. CONCLUSION: CCO was not the starting point of NA action. NA interferes with the structure and function of the cytoplasm and nucleus of malaria parasites and exerts its antimalarial effects in many aspects.

关 键 词：硝基喹啉类 约氏疟原虫 细胞色素C 氧化酶类 肝 

分 类 号：R978.61[医药卫生—药品]