微血管密度与CD105、CD31在胃癌中的表达及意义  

Significance of microvessel density and expressions of CD105,CD31 in gastric carcinoma

作　　者：徐国萍[1] 张林[2] 苗杰[2] 李春荣[2] 金树珍[2] 高不郎[3] 沈惠芬[1] 杨丽荣[1] 

机构地区：[1]大理学院基础医学院病理教研室,云南大理671000 [2]昆明医学院第一附属医院病理科 [3]昆明医学院第一附属医院影像科

出　　处：《胃肠病学和肝病学杂志》2009年第6期524-526,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨胃癌组织中微血管密度(microvessel density,MVD)与CD105、CD31的表达及生物学行为的关系。方法取61例术前未作放、化疗及免疫治疗胃癌病人的外科手术切除标本,采用免疫组织化学技术S-P法检测CD105、CD31的表达,并定量计数胃癌组织微血管。结果胃癌组织中CD105及CD31标记的MVD在与淋巴结转移、肿瘤浸润深度均有显著性差异(P<0.05);Kaplan-Meier法分析显示微血管计数CD105<14个,CD31<34个(200×)的胃癌病人预后较好,而微血管计数CD105≥14个,CD31≥34个(200×)预后较差。结论胃癌MVD与其生物学行为有关,提示肿瘤血管生成分析和微血管密度计数是评价胃癌预后的一项重要参考指标。Objective To investigate the microvessel density （MVD） and the expressions of CD105 and CD31 in the tissue of gastric carcinoma and their relationship with tumor invasion and metastasis, and to evaluate the relationship of MVD value with the prognosis of patients with gastric carcinoma. Methods After operation, section preparation of 61 patients with gastric carcinoma without radiotherapy, chemotherapy or immunotherapy before operation were examined by using S-P immunohistochemical method to detect the expressions of CD105 and CD31 , and the microvessel in the tumor tissue was counted quantitatively. Results Under the field of vision of 200 times, the value of MVD marked with CD105 and CD31 in the gastric carcinoma had significance difference in both the depth of carcinoma invasion and metastasis of lymphatic nodes （P 〈 0.05）. Kaplan-Meier analysis showed that patients with CD105 〈 14 and CD31 〈 34 （200×） had better prognosis and that patients with CD105≥14 and CD31 ≥34 （200×） did not. Conclusion The value of MVD in the gastric cancer is correlated with the biological behavior of the carcinoma, which suggests that the analysis of the genesis of tumor vessel and the count of MVD are an important index in evaluation the prognosis of patients with gastric cancer.

关 键 词：胃癌 CD105 CD31 微血管密度 免疫组化 

分 类 号：R735.2[医药卫生—肿瘤]