胃粘膜癌前病变患者胃液中CEA、CA19-9、CA72-4检测的临床意义  

THE CLINICAL SIGNIFICANCE OF COMBINING DETECTION WITH CEA,CA19-9 AND CA72-4 IN THE PATIENTS OF GASTRIC PRECANCEROUS LESION

作　　者：黄艳春[1] 付文金[1] 戴艳清[1] 杜秀珍[1] 

机构地区：[1]东莞市厚街医院内镜中心,广东东莞523945

出　　处：《牡丹江医学院学报》2009年第3期11-13,共3页Journal of Mudanjiang Medical University

摘　　要：目的:通过对胃粘膜癌前病变患者胃液CEA、CA19-9、CA72-4的单检及联合检测,探讨其临床意义。方法:采用双抗体夹心法对胃液中CEA、CA19-9、CA72-4进行检测,并对胃粘膜癌前病变患者进行分组,包括萎缩性胃炎伴非典型增生共90例:分轻(B)、中(C)、重度(D)三组,分别各30例,萎缩性胃炎伴肠上皮化生30例(E组),萎缩性胃炎伴肠上皮化生及非典型增生30例(F组),与对照组(A组):慢性浅表性胃炎或正常胃粘膜30例进行对比分析,结果进行统计学处理。结果:萎缩性胃炎伴非典型增生,萎缩性胃炎伴肠上皮化生,萎缩性胃炎伴肠上皮化生及非典型增生各组与浅表性胃炎或正常胃粘膜对照组比较有显著性差异。CEA、CA19-9、CA72-4三种肿瘤标志物单检及联合检测的灵敏度、特异度分别为:CEA:56.32%,61.28%,CA19-9:63.28%,63.20%,CA72-4:69.27%70.32%,CEA+CA19-9:69.90%,70.92%,CEA+CA72-4:72.56%,73.36%,CA19-9+CA72-4:72.98%,73.32%,CEA+CA19-9+CA72-4:75.26%,76.38%。结论:胃液中CEA、CA19-9、CA72-4单检或联合检测均能反映出胃粘膜癌前病变的程度,提示对胃的癌前疾病进行追踪随诊,对早期发现胃癌有重要的临床意义。Objective：To explore the clinical significance of Combining detection with CEA,CA19 -9 and CA72 -4 in the patients of gastric precancerous lesion. Methods ： Double antibody sandwich methods were adopted to detect these expression such as CEA, CA19 - 9 and CA72 - 4 in gastric juices of gastric precancerous lesion patients. These patients were divided into groups as the fellowings ： 1 ） Atrophic Gastritis accompanied with untypical hyperplasia. There were 90 patients in the group, and then were subdivided into mild sub- group（30 patients）, midrange subgroup（ 30 patients）, and severe subgroup（ 30 patients）. 2）Atrophic Gastritis accompanied with intes- tinal metaplasia. There were 30 patients in the group. 3 ） Atrophic Gastritis accompanied with intestinal metaplasia and untypical hyper- plasia. There were 30 patients in the group. 4） Control group included 30 patients suffered from chronic superficial gastritis. Contrastive analysis and statistical treatment were used with these detection data. Results：There were significant differences in these indexes such as CEA, CA19 -9 and CA72 -4 between some group and another group. The sensibility of these tumor marker is： CEA：56. 32 % , CA19 - 9：63.28% , CA72 - 4 ： 69. 27% , CEA ＋ CA19 - 9 ： 69.90%, CEA ＋ CA72 - 4 ： 72. 56% , CA19 - 9 ＋ CA72 - 4 ： 72. 98%, CEA ＋ CA19 - 9 ＋ CA72 - 4：75.26% ,The specificity of these tumor marker is： CEA 61.28% , CA19 - 9 63.20 % ,, CA72 - 4 70.32%,CEA＋ CA19-9 70.92%,CEA＋ CA72-4 73.36%,CA19-9 ＋ CA72-4 73.32%,CEA＋ CA19-9 ＋ CA72-4 76. 38%. Conclusion：Detection of these expression of tumor markers such as CEA, CA19 -9 and CA72 -4 in gastric juices can show severity of gastric precancerous lesion, so it plays an very importmant role in clinical outcome of gastric precancerous lesion.

关 键 词：胃液 CEA CA19-9 CA72-4 胃粘膜癌前病变 双抗体夹心法 

分 类 号：R57[医药卫生—消化系统]