雷贝拉唑治疗Hp阳性消化性溃疡疗效观察  

The Clinical Observation of Rabeprazole in Treating Positive Peptic Ulcer Patients with Helicobacter Pylori(HP)

作　　者：余建新 罗光辉[2] 宋涛[2] 

机构地区：[1]广东省新会司前中心卫生院内科,广东新会529100 [2]南方医科大学附属新会医院,广东新会529100

出　　处：《河北医学》2009年第7期799-801,共3页Hebei Medicine

摘　　要：目的：观察雷贝拉唑治疗幽门螺杆菌（Hp）阳性消化性溃疡的愈合率及根除幽门螺杆菌的疗效。方法：治疗组（A组）第1周用雷贝拉唑10mg,1次/d,晨服,阿莫西林1g、克拉霉素0.5g,2次/d,饭前1h服用,连用7d;以后单用雷贝拉唑10mg,1次/d,晨服,连用7d。对照组（B组）第1周用奥美拉唑20mg,阿莫西林1g、克拉霉素0.5g,2次/d,饭前1h服用,连服7d以后单用奥美拉唑20mg,1次/d。饭前1h服用,连服7d;两组均2周为1个疗程,疗程结束后4-6周内进行纤维内镜复查及Hp尿素酶快速诊断试验。对溃疡愈合者,自治疗结束后1年、2年进行随访,内镜复查及Hp尿素酶快速诊断试验,统计溃疡复发率及Hp再染率。结果：治疗后,A组溃疡愈合率为97.1%,B组溃疡愈合率为92.9%,但无显著性差异（P〉0.05）,而Hp清除率A组为95.7%,B组为61.4%,两组差异具有显著性（P〈0.01）;1年溃疡复发率：A组6.8%,B组17.5%;Hp再染率：A组11.9%,B组22.8%;2年溃疡复发率：A组15.3%,B组24.6%;Hp再染率：A组18.6%,B组33.3%,差异均有显著性（P〈0.01）。结论：雷贝拉唑对HP阳性的消化性溃疡有较高的治愈率,疗效比奥美拉唑明显。雷贝拉唑2周为一疗程,是一种高效、短程、安全、更为经济的根除HP和促进溃疡愈合的方案。Objective： To observe the effectiveness and healing rates of Rabeprazole in the treatment of Helicobacter Pylori （ Hp ） positive in peptic ulcer patients. Method ： The treatment group （ A group ） were treated with Rabeprazole 10mg, p. o, q. m, Amoxicillin lg and Clarithromycin 0.5g, p. o, bid, a. c in the first week. And then only treated with Omeprazole 20mg, p. o, q. m for seven days. Check with Fiber endoscope and Hp Urease rapid diagnostic test in the 4th-6th week after the treatment. To the people of ulcer healing, check with Fiber endoscope and Hp Urease rapid diagnostic test after one or two years. Count the rate of ulcer recurrence and re - Hp uptake. Result： After the treatment, ulcer healing rate of A group was 97.1%, and the B group was 92.9%. There$ no significant difference in statistics between two groups （ P 〉 0.05 ）. Hp clearance rate of A group was 95.7%, the B group was 61.4%. There＇s significant difference in statistics between two groups IP 〈0.01 ）. The ulcer relapse rate of A group was 6.8% within one year, and the B group was 17.5%. The Hp re -uptake rate of A group was 11.9%, and the B group was 22.8%. The ulcer relapse rate of A group was 15.3% within two years, and the B group was 24.6%. The Hp re - uptake rate of A group was 18.6%, and the B group was 33.3%. In statistics the two groups have significant difference （ P〈0.01 ）. Conclusion ： Comparing with Omeprazole, Rabeprazole in the treatment of Hp - positive peptic ulcer has a highly efficient, short - range, secure, more economical to eradicate Hp and the promotion of ulcer healing program.

关 键 词：消化性溃疡 雷贝拉唑 奥美拉唑 

分 类 号：R573.1[医药卫生—消化系统]