醒脑静对急性脑梗死患者血清S-100B蛋白的影响  

Effect of Xingnaojing on the Level of Serum S-100B Protein in Patients with Acute Cerebral Infarction

作　　者：陈冰璞[1] 王建民[1] 

机构地区：[1]北京军区总医院采购中心,北京100700

出　　处：《中国药物应用与监测》2009年第3期138-140,共3页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:探讨醒脑静对急性脑梗死患者血清S-100B蛋白水平和临床症状的影响。方法:入选157例急性脑梗死患者随机分为两组,常规治疗相同,治疗组用醒脑静30mg静脉滴注,每天2次,对照组用注射用水,方法疗程同治疗组,共治疗14d。分别在入院0,24,48,72,96,120和144h采血,用ELISA法测定血浆S-100B水平;分别在0,1,2,4和14d进行美国国立卫生卒中量表(NIHSS积分)评定。结果:治疗组与对照组的S-100B水平均在第4天达到高峰,从入院后96h开始,两组的S-100B水平出现显著统计学差异(P<0.05),7d治疗后两组患者血清S-100B水平有极显著统计学差异(P<0.01),醒脑静治疗组的S-100B水平明显低于对照组;两组NIHSS分数均随着治疗时间的增加而呈现下降趋势,在入院1,4,7和14d有显著统计学差异(P<0.05),治疗组在第1,4,7和14d时的NIHSS总分明显低于对照组。结论:醒脑静可改善NIHSS积分,改善神经功能,降低血清蛋白S-100B水平。Objective： To explore the effect of Xingnaojing on the level of serum S-100B protein and recovery of neurological function. Methods： 157 Patients with acute cerebral infarction were randomly assigned to receive Xingnaojing （30 mg by intravenous drip twice a day） for 14 days or placebo. We obtained serum S-100B protein of the patients at admission time and 24, 48, 72, 96, 120 and 144 hours after admission. National institutes health stroke scale scores （NIHSS scores） were evaluated at hospital admission and 1, 2, 4, 14 days after admission. Results： Values of serum S-100B in two groups raised until 4th day, peak value of treatment group was statistically lower than the control one. There were differences in the two groups （P 〈 0.05）. The S-100B serum value obtained 144 h after stroke in treatment group was higher than the control group. There were significant differences in the two groups （P 〈 0.01）. NIHSS scores in two groups decreased after admission at 1, 4, 7 and 14 days, scores in the treatment group at 1, 4, 7 and 14 days were lower than the control group （P 〈 0.05）. Conclusion： Xingnaojing can decrease NIHSS score, improve neurological function and decrease S-100B serum concentration.

关 键 词：醒脑静 急性脑梗死 S-100B蛋白 美国国立卫生卒中量表 

分 类 号：R743.33[医药卫生—神经病学与精神病学]