联合应用STR和SRY基因分型技术分析性分化异常者  

Application of STR and SRY Techniques in Analyzing the Sex Reversal Syndrome Patient

作　　者：林源[1] 李成涛[1] 

机构地区：[1]司法部司法鉴定科学技术研究所上海市法医学重点实验室,上海200063

出　　处：《中国司法鉴定》2009年第3期83-85,共3页Chinese Journal of Forensic Sciences

基　　金：中央级科研院所社会公益研究资助项目(GY0803)

摘　　要：目的对Amelogenin分型结果为"X,X"的一名"男孩"进行性别确认。方法采用STR检测和SRY基因检测技术进行分析。结果孩子STR、X-STR的检验结果符合女性性别特征,SRY基因检测结果为阴性。结论应用STR、X-STR检测和SRY基因检测技术可以确证"男孩"Amelogenin基因座结果为"X,X",推断其患有"46,XX"男性性反转综合症。Objective To confirm a boy＇s gender character whose genotype of Amelogenin locus was ＂X,X＂. Methods Samples of the boy and his father were analyzed by PCR at both SRY gene and STR loci on autosome and Y,X chromosome. Results The boy＇s gender was confirmed as ＂X,X＂ by the detection results of Amelogenin, Y-STRs and X-STRs. Conclusion The boy suffered from ＂46, XX＂ sex reversal syndrome.

关 键 词：性分化异常 X-STR检测 SRY 

分 类 号：Q987[生物学—遗传学] Q254[生物学—人类学]