艾司西酞普兰与帕罗西汀治疗抑郁症的对照研究  

Comparative study of Escitalopram and Paroxetine in the treatment of depression

作　　者：卢玲[1] 胡君[1] 

机构地区：[1]沈阳市精神卫生中心,辽宁沈阳110168

出　　处：《中国民康医学》2009年第12期1372-1372,1383,共2页Medical Journal of Chinese People’s Health

摘　　要：目的：比较艾司西酞普兰与帕罗西汀治疗抑郁症的疗效及安全性。方法：将60例抑郁症患者随机分为两组,分别用艾司西酞普兰和帕罗西汀治疗,疗程6周。用汉密尔顿抑郁量表（HAMD）评定临床疗效,副反应量表（TESS）评定不良反应。结果：艾司西酞普兰组显效率66%,有效率88%;帕罗西汀组为62%,83%。两组疗效相仿。在治疗2周末时,艾司西酞普兰组减分多于帕罗西汀组,差异有显著性。两组不良反应均轻微。结论：艾司西酞普兰和帕罗西汀抗抑郁疗效肯定,不良反应轻。Objective： To compare the efficacy and side effects of Escitalopram and paroxetine in the treatment of depression. Methods： Sixty patients with depression were randomly assigned to Escitalopram group and paroxetine group for 6 weeks. The efficacy was evaluated with Hamilton depression rating scale（ HAMD）, and the side effects were evaluated with treatment emergent aymptoms scale（TESS）. Results： Total clinieal effective rate and response rate in Escitalopram group and paroxetine group were 66% and 88% ;62% and 83% respectively. No significant difference was found in clinical efficacy between two groups. However, the total score of HAMD in Escitalopram group was significantly lower than that in paroxetine group after two - week treatment. The side effects of bith groups were fewer and lighter. Conclusion： Both Escitalopram and paroxetine are effective antidepressants with fewer side effects.

关 键 词：艾司西酞普兰 帕罗西汀 抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]