电压门控性钠通道亚型和神经病理性疼痛  

Voltage-gated sodium channel subtype and neuropathic pain

作　　者：吴宝红[1] 王永安[1] 郑建全[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《国际药学研究杂志》2009年第3期189-193,共5页Journal of International Pharmaceutical Research

摘　　要：神经病理性疼痛是神经系统损伤引起的一种慢性疼痛。感觉神经元上的电压门控性钠通道在多种由外周神经损伤引起的神经病理性疼痛中具有重要的作用。近年来,随着对钠通道亚型在神经病理性疼痛发病机制中作用的阐明,发展特异性的钠通道亚型阻断药物将成为治疗神经病理性疼痛的重要研究方向。Neuropathic pain is a chronic pain caused by nervous system damage. Voltage-gated sodium channels on sensory neurons play an important role in a variety of neuropathic pains caused by peripheral nerve injury. In recent years, with the elucidation about isoforms of sodium channels in pathogenesis of neuropathic pain, specific blockers of sodium channel subtypes will become an important research direction to relieve neuropathic pain.

关 键 词：电压门控钠通道亚型 神经病理性疼痛 钠通道阻断剂 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R971.1[医药卫生—临床医学]