视黄醇受体与肺癌变  

Retinol Receptors and Lung Carcinogenesis

作　　者：邱琳[1] 孙强[1] 

机构地区：[1]中国医科大学

出　　处：《医学综述》2009年第13期1957-1959,共3页Medical Recapitulate

摘　　要：一些体外、体内试验证实了类视黄醇（维生素A类似物）在癌变前和癌变中的正面和负面作用。由于在细胞分化、生长、增殖和凋亡方面的多种调节作用，类视黄醇已被用作化学预防剂和抗癌剂。其调节作用是通过两种核受体的相互作用实现的：视黄酸受体和类视黄醇X受体。最新研究逐渐阐明了类视黄醇的功能、信号通路及早期化学预防失败的原因。本文将阐述视黄醇受体在肺癌变方面作用的基本和最新的认识。Many experiments in vivo and in vitro have indicated the positive and negative effect of retinoids（ vitamin A analogs）in premalignant and malignant lesions. Because of their pleiotropic regulatory function in cell differentiation, growth, proliferation and apoptosis, retinoids have been used as chemopreventive and anticaneer agents. Their regulation is implemented through interaction between two types of nuclear receptors： retinoic acid receptor（RAR） and retinoid X receptor（RXR）. Recent investigations have gradually elucidated the function of retinoids and their signaling pathways, as well as the reason resulting in failure of secondary chemoprophylaxis ,This article reviews the progress of retinal receptor about its effect on lung carcinogenesis,

关 键 词：视黄醇受体 肺癌变 类视黄醇 视黄酸受体 类视黄醇X受体 

分 类 号：R734.2[医药卫生—肿瘤]