喹硫平与奋乃静治疗老年脑血管病伴发精神障碍的对照研究  

Comparative study of Quetiapine and Perphenazin on the treatment of mental disorders due to vascular disease in the elderly

作　　者：成敬[1] 李承晏[2] 阳胜秋[1] 陈耀银[1] 王晓萍[1] 王高华[1] 郭俊慧[1] 

机构地区：[1]武汉大学人民医院精神卫生中心,湖北省武汉市430060 [2]武汉大学人民医院神经科,湖北省武汉市430060

出　　处：《实用老年医学》2009年第3期205-208,共4页Practical Geriatrics

摘　　要：目的比较喹硫平与奋乃静治疗≥75岁老年人脑血管病伴发精神障碍的疗效及安全性。方法将60例高龄脑血管病伴发精神障碍患者随机分为2组,喹硫平组30例,奋乃静组30例,分别给予2药治疗6周。采用阳性和阴性症状量表(PANSS)、临床疗效总评量表(CGI)评定临床疗效,副反应量表(TESS)及有关实验室检查评定不良反应。t检验、秩和检验、χ2检验对数据进行统计分析。结果治疗6周后2药的疗效近似(P>0.05)。在治疗第1周末喹硫平组PANSS总分的减分率显著高于奋乃静组(P>0.05)。奋乃静组肌张力增高、静坐不能发生率显著高于喹硫平组(P<0.01或P<0.05)。结论喹硫平治疗≥75岁老年人脑血管病伴发精神障碍疗效肯定、起效快、不良反应较奋乃静轻微,更适用于老年患者。Objective To compare the efficacy and side effects of Quetiapine and Perphenazin on the treatment of mental disorders due to vascular disease in the eldely. Methods A total of 60 elderly patients with mental disorders due to vascular disease were randomly assigned to two groups to receive Quetiapine or Perphenazin for 6 weeks. PANSS. CGI and TESS were adopted to evaluate the efficacy and side effects before and after 1,2, 4 and 6 weeks of the treatment. Resuits After 6 weeks of treatment, the response rate between the Quetiapine and the Perphenazin groups was similar （70. 00% vs 66. 67%, P 〉 0. 05 ）. The decreasing radio of PANSS total score was significantly higher in Quetiapine group than that in the Perphenazin group at the 1 week of treatment （ P 〈 0. 05 ）. TESS showed the incidence of hypermyotonia and akathisia were higher in Perphenazin group than those in Quetiapine group （ P 〈 0. 01 or P 〈 0. 05 ）. Conclusions Quetiapine and Perphenazin both provide valuable treatment options for the elderly with mental disorders due to vascular disease. Quetiapine is rapid in action, safe and less side effects in treating elderly patients with mental disorders due to vascular disease.

关 键 词：喹硫平 奋乃静 脑血管病伴发精神障碍 老年人 

分 类 号：R746.1[医药卫生—神经病学与精神病学]