颈动脉支架术治疗急性脑梗死中神经元特异性烯醇化酶的临床意义  

Clinical significance of serum neuron specific enolase for patients with acute cerebral infarction receiving carotid artery stenting

作　　者：杨美兰 张志[1] 曲辉[2] 黄宗清 

机构地区：[1]深圳市第四人民医院神经内科,广东省深圳市518003 [2]北京天坛医院神经内科,北京市100050

出　　处：《实用老年医学》2009年第3期220-222,共3页Practical Geriatrics

基　　金：深圳市福田区科研立项(TF200525)

摘　　要：目的探讨颈动脉支架术(CAS)治疗急性脑梗死(CI)的疗效及神经元特异性烯醇化酶(NSE)的临床意义。方法应用酶联免疫吸附法对18例行CAS治疗(CAS组)及25例予药物治疗的CI患者(药物组)的NSE水平进行动态观察,并随病程进行美国国立卫生研究院卒中量表(NIHSS)评分来评定其神经功能。结果实验组血清NSE水平显著高于正常人组(P<0.01),第2天起NSE表达均呈下降趋势,但CAS组下降更明显,第7、14天CAS组与药物组进行组间比较具有统计学差异(P<0.05);神经功能的变化趋势与NSE的表现相似。结论CAS是一种治疗CI的有效措施,NSE可作为检测CAS疗效、预后的定量指标。Objective To investigate the curative effect of carotid artery stenting（CAS） and the clinical value of serum neuron specific enolase（NSE） levels in patients with acute cerebral infarction. Methods Serum NSE levels were measured with ELISA in 18 patients receiving CAS and 25 patients receiving drug treatment. At the same time National Institutes of Health Stroke Scale （NIHSS） measurement was performed. Results The serum NSE levels of the experiment group were significantly higher than those in control group （P 〈0. 01 ）. And then the level of NSE in the experiment group showed descending trend since the second day. But the CAS group showed more obviously. The difference between CAS group and drug group was significant （ P 〈 0. 05 ）. Neurological improvement showed the same tendency with NSE. Conclusions CAS has effects in treating acute cerebral infarction. NSE can be a biochemical marker for the curative effect and prognosis of CAS.

关 键 词：急性脑梗死 颈动脉支架术 神经元特异性烯醇化酶 

分 类 号：R743.3[医药卫生—神经病学与精神病学]