雌激素受体β亚型和Survivin在甲状腺肿瘤组织中表达的意义  

Expression and significance of ERβ and survivin in thyroid tumors

作　　者：高金生[1] 金东岭[1] 刘现军[1] 赵兴全[2] 

机构地区：[1]河北工程大学医学院病理教研室,邯郸056002 [2]河北工程大学附属医院心内科

出　　处：《肿瘤研究与临床》2009年第6期380-382,共3页Cancer Research and Clinic

基　　金：河北省科技攻关项目（06276102D-55）

摘　　要：目的探讨雌激素受体β亚型（ERβ）和凋亡抑制蛋白Survivin在甲状腺肿瘤组织中的表达及其意义。方法采用免疫组织化学SP法对2003年2月至2007年12月收检的125例甲状腺肿瘤组织蜡块（86例甲状腺癌，39例甲状腺腺瘤）和10例正常甲状腺组织中ERβ和Survivin的表达进行检测。结果ERβ不仅表达于甲状腺上皮细胞的细胞核和细胞质，在间质中也有表达。ERβ在甲状腺癌、甲状腺腺瘤和正常甲状腺组织中的阳性表达率分别为83．72％、51．28％和20．00％，甲状腺癌中ERβ的表达显著高于其他两组（P〈0．05）。Survivin在甲状腺癌、甲状腺腺瘤中的阳性表达率分别为59．30％、17．95％，在正常甲状腺组织中无表达。甲状腺癌中Survivin的表达显著高于其他两组（P〈0．05）。甲状腺癌ERβ和Survivin的异常表达与肿瘤分期以及淋巴结转移有关（P〈0．05）。结论ERβ的表达可能对甲状腺癌发生过程中的细胞增生具有促进作用；ERβ和Survivin的异常表达与甲状腺癌的侵袭和转移有关。Objective To investigate the expression and clinical significance of the estrogen receptor beta isoforms and survivin in thyroid tumors. Methods The pathological data of 125 patients with thyroid tumors were, colIected from june 2003 to june 2007 in our institution, including thyroid carcinoma （86 cases）, thyroid follicular adenoma （39 cases） and normal thyroid tissue （10cases）. SP immunohistochemistry was used to measure the expressions of ERβ3 and survivin in the thyroid tumors. Results ERβ not only was detected in the thyroid epithelial cell plasma and nuclear, but also in the stroma. The positive rate of ERβ in cases with thyroid carcinoma, adenoma and normal thyroid tissue were 83.72 %, 51.28 % and 20.00 % respectively. There was significant difference between carcinoma and the adenoma or normal thyroid tissue （P 〈 0.05）. The positive rate of survivin in cases with carcinoma, adenoma and normal thyroid tissue were 59.30 %, 17.95 % and 0 respectively. There was significant difference between carcinoma and the adenoma or normal thyroid tissue （P 〈0.05）. The expressions of ERβ and survivin correlated with TNM staging and lymph node metastasis of thyroid carcinoma （P 〈0.05）. Conclusion ERβ may play a role in accelerating proliferation in the occurrence of the thyroid carcinoma. The expressions of ERβ and survivin are related to invasion and metastasis of thyroid carcinoma.

关 键 词：甲状腺肿瘤 雌激素受体Β SURVIVIN 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]