五天与七天HA方案治疗慢性粒细胞白血病慢性期的临床分析  

Comparative analysis of the curative effect on CML in chronic phase by different courses of HA combination regimen

作　　者：孙爱红[1] 何斌[1] 孙梅[1] 汪中强[1] 张育[1] 顾健[1] 

机构地区：[1]扬州大学临床医学院江苏省苏北人民医院血液科,225001

出　　处：《白血病．淋巴瘤》2009年第6期353-355,共3页Journal of Leukemia & Lymphoma

摘　　要：目的观察5d与7dHA联合化疗方案对慢性粒细胞白血病慢性期（CML—CP）的临床疗效和毒副作用。方法选择18例初诊CML患者为治疗组，化疗方案为HA×5d，其中HHT4mg／d，Ara—C200mg／d；回顾分析18例类似患者，HA×7d。主要观察外周血白细胞数、脾脏大小、染色体及化疗毒副作用。结果5d和7dHA化疗方案治疗CML—CP的短期完全缓解率分别为50．0％和61．1％，但差异无统计学意义（P〉0．05）。其中骨髓移植率分别为0、16．7％，差异有统计学意义（P〈0．05）。结论两组临床效果接近，但是7dHA化疗方案后骨髓抑制发生率高。Objective To compare the efficacy and adverse effects of 5 days＂ and 7 days＂ course of combination chemotherapy regimen HA in the treatment of chronic phase of chronic myelogenous leukemia （CML-CP）. Methods 18 cases of CML-CP had received 5 days＂ course of combination chemotherapy regimen HA including homoharringtonine 4 mg/d and cytarabine 200 mg/d for 5 days. At the same time, another 18 patients diagnosed as CML-CP who were given 7 days＂ course of HA regimen including homoharringtonine 4 mg/d and cytarabine 200 mg,/d for 7 days were compared on the efficacy including peripheral white blood cells, spleen size and cytogenetic responses and adverse effects. Results The complete remission（CR） rate was 50.0 % and 61.1% in 5 days＂ and 7 days＂ treated groups, respectively （P 〉0.05）. The incidence of severe bone marrow suppression in 7 days＂ group（16.7 %） was higher than that in 5 days＂ group（0）（P 〈0.05）. Conclusion The 5 days＂ course of combination chemotherapy HA regimen is same as 7 days＂ course of HA regimen about their curative effects in CML-CP. But the incidence of severe bone marrow suppression in 7 days＂ group（16.7 %） was higher than that in 5 days＂ group （0）.

关 键 词：白血病 髓样 慢性 HA联合化疗方案 

分 类 号：R733.72[医药卫生—肿瘤] R521[医药卫生—临床医学]