黏膜相关淋巴组织淋巴瘤病因学及分子遗传学研究进展  

Recent advances in aetiology and molecular genetics of MALT lymphoma

作　　者：张雪梅(综述)[1] 叶洪涛(审校)[2] 

机构地区：[1]广西医科大学病理学教研室,南宁530021 [2]桂林医学院病理学教研室

出　　处：《白血病．淋巴瘤》2009年第6期376-379,共4页Journal of Leukemia & Lymphoma

摘　　要：黏膜相关淋巴组织（MALT）淋巴瘤是起源于淋巴结外MALT的低度恶性B细胞性淋巴瘤。除早期发现胃MALT淋巴瘤与幽门螺杆菌（HP）感染有关外，最近又发现一些与其他部位MALT淋巴瘤有关的病原体。t（11；18）（q21；q21）、t（1；14）（p22；q32）、t（14；18）（q32；q21）是MALT淋巴瘤特征性的染色体异常，在不同部位的MALT淋巴瘤中发生率也不同。这三种染色体易位产物激活共同的分子通路NF—KB通路。另外还发现了一些新的基因异常。这些病因学及分子遗传学的研究有助于了解MALT淋巴瘤的发病机制，也有助于早期诊断和合理治疗。Mucosa-associated lymphoid tissue （MALT） lymphoma is a low grade B-cell lymphoma arising from MALT of extra-nodal. A link of Helicobacter pylori（HP） infection with gastric MALT lymphoma was confirmed in the early years. Currently, growing evidence indicates that development of non-gastric MALT lymphoma is also associated with infections by microbial pathogens, t（ll;18）（q21;q21）,t（1;14）（p22;q32） and t （14;18）（q32;q21） are specifically associated with MALT lymphoma, which occur at variable incidences in MALT lymphoma of different sites. The oncogenic activity of these three chromosome translocations is linked by antigen receptor-mediated NF-KB activation.In addition, a number of novel genetic abnormalities have been recently identified in MALT lymphoma. The findings of these microbial pathogens and molecular genetics would be helpful in better understanding the pathogenesis of MALT lymphoma and also useful for the diagnosis at early stage and proper treatments of MALT lymphoma.

关 键 词：淋巴瘤 黏膜相关淋巴样组织 基因 染色体 分子生物学 

分 类 号：R733.4[医药卫生—肿瘤] R749.16[医药卫生—临床医学]