神经元烟碱α4β2亚型受体与神经系统疾病的关系  

Relationship between neuronal α4β2 nicotinic acetylcholine receptor and neurological diseases

作　　者：聂惠贞[1] 李薇[2] 聂瑞丽[3] 殷明[1] 

机构地区：[1]上海交通大学药学院神经药理学实验室,上海200240 [2]上海交通大学药学院公共技术实验室,上海200240 [3]山东省邹城市妇幼保健院,邹城273500

出　　处：《上海交通大学学报（医学版）》2009年第6期744-746,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(30572179)~~

摘　　要：神经元烟碱受体(nAChRs)α4β2亚型是中枢神经系统分布最为广泛的烟碱受体亚型,占脑内与烟碱有高亲和力的nAChRs的90%,主要分布在前脑、顶叶和颞叶皮质、海马、基底神经节和小脑。对基因敲除小鼠的研究提示,α4β2受体参与机体的发育、衰老、神经存活、学习记忆及痛觉调控,对突触前膜γ-氨基丁酸释放和中脑多巴胺能神经控制也十分重要。基于α4β2亚型nAChRs的这些生理功能,提示其与疼痛、阿尔茨海默病、帕金森病等多种神经系统疾病的发生和发展有关。Neuronal α4β2 nicotinic acetylcholine receptors （nAChRs） are the most widespread subtypes in central nervous system, α4β2 nAChRs mainly exist in procerebrum, parietal lobe cortex, temporal lobe cortex, hippocampus, basal ganglion and cerebellum. Researches on gene knock-out mice have demonstrated that α4β2 receptors participate in the development, aging, neuron survival, pain, and learning and memory, and are also involved in gamma-aminobutyric acid release and dopaminergic function. Studies have disclosed that α4β2 nAChRs relate to the development of variety of neurological diseases, including pain, Alzheimer＇ s disease and Parkinson＇s disease.

关 键 词：神经元烟碱受体 α4β2亚型 神经系统疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]