辛伐他汀及阿司匹林干预对颈动脉粥样硬化的影响  

Effects of intervention with Simvastatin and Aspirin on carotid artery atherosclerosis

作　　者：郑金书 王青银 王庆祝[1] 杨山[1] 李宇[1] 

机构地区：[1]安徽省滁州市第二人民医院神经内科,239001

出　　处：《临床神经病学杂志》2009年第3期219-221,共3页Journal of Clinical Neurology

摘　　要：目的观察辛伐他汀及阿司匹林干预对颈动脉粥样硬化的影响。方法120例合并颈动脉粥样硬化及血脂异常的缺血性脑血管病患者随机分为辛伐他汀组、阿司匹林组及辛伐他汀+阿司匹林组,分别给予相应的药物治疗6个月;比较3组治疗前后血清C-反应蛋白(CRP)、血脂水平及颈动脉内-中膜厚度(IMT)、颈动脉斑块面积的变化及脑血管事件复发率。结果3组治疗后血清CRP水平均较治疗前显著降低(均P<0.05);辛伐他汀组和辛伐他汀+阿司匹林组治疗后颈动脉IMT、斑块面积及血脂水平显著降低(均P<0.05);阿司匹林组治疗前后颈动脉IMT、斑块面积及血脂水平差异无统计学意义;辛伐他汀+阿司匹林组治疗后各项指标较另外两组改善更明显(均P<0.05);3组患者脑血管病复发率差异无统计学意义。结论辛伐他汀和阿司匹林联合干预对降低CRP水平,延缓和逆转颈动脉粥样硬化优于单一使用辛伐他汀或阿司匹林,并可预防脑血管病复发。Objective To observe the effects of intervention with Simvastatin and Aspirin on carotid artery atherosclerosis（CAA）. Methods 120 patients with ischemie cerebrovaseular disease and complicated CAA and blood-lipid abnormality were randomly divided into the Simvastatin group, Aspirin group, Simvastatin ＋ Aspirin group. Each group received corresponding therapy for 6 months. The changes of serum C-reactive protein （CRP） level, blood-lipid level, the carotid artery intimal and media thickness （IMT）, the plaque areas before and after treatment and the recurrence rate of cerebrovaseular event among the 3 groups were compared. Results Compared with before treatment, the levels of serum CRP were significantly decreased in the 3 groups after treatment （ all P 〈 0. 05 ） ; the carotid artery IMTs, plaque areas and blood-lipid levels in Simvastatin group and Simvastatin ＋ Aspirin group were significantly decreased too（ all P 〈 0. 05 ） ; but there was no significant diference of the carotid artery IMT, the plaque area and the blood-lipid level before and after treatment in Aspirin group. After treatment, the improved indexes in Simvastatin ＋ Aspirin group were much better than those in other two groups （all P 〈 0. 05 ）. The recurrence rates of cerebrovascular event among the 3 groups was no significant difference. Conclusion Simvastatin combined with Aspirin is more effectively delay and reverse the progression of CAA and decrease the level of serum CRP than the therapy with Simvastatin or Aspirin only,and may prevent recurrence of eerebrovascular disease.

关 键 词：颈动脉粥样硬化 辛伐他汀 阿司匹林 

分 类 号：R743.3[医药卫生—神经病学与精神病学]