ESR1基因多态性与原发性肝癌发生的相关性研究  

Study on the relationship between polymorphism of ESR1 gene and primary liver cancer

作　　者：楼建军[1] 谢裕安[2] 罗小玲[2] 匡志鹏[2] 杨志国[2] 吴昊[2] 

机构地区：[1]广西医科大学研究生学院 [2]广西医科大学肿瘤医院,南宁530021

出　　处：《中国癌症防治杂志》2009年第2期98-100,共3页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

基　　金：国家自然科学基金项目(NO 30660204)

摘　　要：目的探讨广西扶绥县原发性肝癌(PLC)患者肝癌相关基因ESR1遗传多态性与肝癌发生的关系。方法以50例壮族、50例汉族PLC患者,37例壮族、37例汉族高危人群,30例壮族、30例汉族正常人群为研究对象。选取ESR1基因SNP rs 9340772位点作为遗传标志,用聚合酶链式反应-限制性片段长度多态性方法(PCR-RFLP)检测ESR1基因多态性及其基因突变的分布频率。结果肝癌组、高危人群及正常人群ESR1基因的SNP rs 9340772位点均未发生突变,3组比较差异无统计学意义(P>0.05)。结论ESR1基因SNP rs 9340772位点多态性与原发性肝癌的发生无关。Objective To study the association between polymorphism of ESR1 gene in primary liver cancer （PLC） in Fusui area of Guangxi. Methods 50 cases of PLC with Zhuang nationality, 50 cases of PLC with Han nationality, 37 cases from high risk population with Zhuang nationality, 37 cases from high risk population with Han nationality, 30 cases from normal population with Zhuang nationality and 30 cases from normal population with Han nationality were enrolled in this study. SNP locus rs 9340772 of ESR1 gene was selected as genetic marker. The genotypes and genetic mutation frequency of all the cases were detected by polymerase chain reaction combined with restriction fragment polymorphism method （PCR-RFLP）. Results There was no mutation in SNP locus rs 9340772 of ESR1 in PLC group, the high risk population group and the normal population group. The expression of ESR1 showed no statistically significant difference among the three groups （ P 〉 0. 05 ）. Conclusion Polymorphism SNP locus rs 9340772 of ESR1 gene is not associated with PLC.

关 键 词：原发性肝癌 雌激素受体 基因多态性 

分 类 号：R735.7[医药卫生—肿瘤]