甲硝唑及注射液中2-甲基-5-硝基咪唑的GC测定  

Determination of 2-Methyl-5-nitroimidazole in Metronidazole and its Injection by GC

作　　者：韩学静[1] 宋更申[1] 张毅[1] 夏国龙 

机构地区：[1]河北省药品检验所,石家庄050011 [2]石家庄四药有限公司

出　　处：《中国药事》2009年第6期535-537,共3页Chinese Pharmaceutical Affairs

摘　　要：目的建立了GC法测定甲硝唑及注射液中2-甲基-5-硝基咪唑。方法采用DB-624毛细管柱,FID检测器,50%甲醇为溶剂。结果2-甲基-5-硝基咪唑加样回收率为99.6%,RSD=1.0%(甲硝唑原料);98.0%,RSD=1.5%(甲硝唑葡萄糖注射液)。结论本方法准确、可靠,可用于甲硝唑及含甲硝唑的注射液中2-甲基-5-硝基咪唑的限量控制。Objective A GC method was established for determination of 2-Methyl-5-nitroimidazole in metronidazole and its injection. Methods A DB-624 capillary column was used, with FID as detector and 50% methanol as the solvent. Results The average recovery of 2-Methyl-5-nitroimidazole was 99.6 % （RSD =1.0%, metronidazole） and 98.0% （RSD= 1.5%, Metronidazole and Glucose Injection） . Conclusions The method is accurate and reliable. It can be used for determination of 2-Methyl-5-nitroimidazole in metronidazole and its injection.

关 键 词：甲硝唑 注射液 GC 2-甲基-5-硝基咪唑 测定 

分 类 号：R917[医药卫生—药物分析学]