透明质酸／果胶复合物的研究  

Research on Hyaluronic Acid and Pectin Complex

作　　者：王书红[1,2] 蔡继业[1] 胡怡[1] 

机构地区：[1]暨南大学生命科学技术学院化学系,广州510632 [2]安阳工学院化学与环境工程系,安阳455000

出　　处：《生物医学工程学杂志》2009年第3期561-565,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金重点项目资助(30230350);国家“十五”973重大项目子项目资助(2001CB510101)

摘　　要：将果胶溶液与透明质酸溶液混合以制备不同比例的共混液,用红外光谱仪和原子力显微镜对透明质酸/果胶复合物进行了表征,结论如下:透明质酸和果胶分子间以较多的氢键结合,当透明质酸、果胶质量比为1∶5时,两者可以很好地复合、相容,形成均一的球状微粒复合膜。本研究旨在以果胶易胶凝的特性影响透明质酸的水溶性,并增强透明质酸的黏性及其生物功能,提高这类复合物在生物医学工程领域的应用价值,为新型医药材料的研发提供理论和数据支持。; Several complexes with different mass ratios of hyaluronic acid to pectin were studied using AFM and IR at the room temperature kept by air conditioning. The results showed that hyaluronic acid and pectin were in the state of being complex and were consistent when the concentrations of hyaluronic acid and pectin were above 1 mg/ml and 5 mg/ml respectively, and the mass ratio was 1 ： 5. The complex self-assembled to composite grain-shaped film. In comparison with simple hyaluronic acid, the viscosity of hylauronic acid and pectin complex was stronger, and water-solubility was lower. The complex has the bio-funetion of both hylauronic acid and pectin and has wide application potential in the field of biomedical engineering.

关 键 词：透明质酸 果胶 原子力显微镜 红外光谱仪 

分 类 号：R318.08[医药卫生—生物医学工程]