人工视网膜关键技术问题的探讨  

A Discussion about Key Issues in Retinal Prosthesis

作　　者：彭承琳[1] 夏露[1] 王星[1] 郑尔信[1] 

机构地区：[1]重庆大学生物医学与电子工程研究所,重庆400044

出　　处：《生物医学工程学杂志》2009年第3期671-675,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30470469);重庆市自然科学基金资助项目(CSTC2006BB3146)

摘　　要：视网膜色素变性(RP)和老年黄斑病变(AMD)是致盲的两个重要病因。视网膜修复技术通过在视网膜下或视网膜外植入微电子芯片或微电极阵列来刺激残留的功能正常的内层细胞而产生光影,从而恢复患者的部分视觉。人工视网膜芯片技术已成为视觉功能修复领域的研究热点,随着研究的深入,其临床应用仍有许多问题亟待解决。本文简介了人工视网膜技术的原理和各国的研究现状,深入探讨了影响视网膜技术临床应用的关键问题,并提出了部分意见和建议。Retinitis pigmentosa （RP） and age-related macular degeneration （AMD） are two predominant causes of visual deterioration. Retinal prosthesis embeds a micro-electric chip or a micro-photoelectric diode array in the subretina or epi-retina, which is used to stimulate the remainder of inner retina, so as to restore some degree of sight. Retinal prosthesis has attracted most attention in the field of artificial visual function recovery, and along with deepgoing research, many issues need to be resolved. In this paper, the theory of retinal prosthesis and the status quo of research in many countries are introduced, the key issues which influence the application of the retinal prosthesis are discussed in detail, and some notions and advices are presented.

关 键 词：视网膜修复 微光电二极管阵列 微电子芯片 电极CMOS工艺 

分 类 号：R774.1[医药卫生—眼科] R318.1[医药卫生—临床医学]