SLeX和p16在甲状腺乳头状癌中的表达及其意义  

Significance of expression of SLeX and p16 in papillary thyroid carcinoma and their relationships

作　　者：尚培中[1] 王兵[2] 万立 张金江[1] 谷化平[1] 

机构地区：[1]解放军第二五一医院普通外科,张家口075000 [2]河北北方学院附属第一医院普通外科,张家口075000 [3]河北省赤城县妇幼保健院外科,张家口075500

出　　处：《中华内分泌外科杂志》2009年第3期151-153,共3页Chinese Journal of Endocrine Surgery

基　　金：基金项目：北京军区医学科学研究“11·5”计划课题（06BJ002）

摘　　要：目的探讨甲状腺乳头状癌（PTC）组织SLeX和p16基因蛋白表达与肿瘤侵袭转移的关系。方法应用微波-链霉菌素-生物素（微波-LSAB）法检测69例PTC组织SLeX和p16蛋白的表达。结果SLeX和p16阳性率分别为69．6％和58．0％，伴有浸润和颈部淋巴结转移者SLeX阳性表达率均显著高于无浸润和无淋巴结转移者（P〈0．05），而p16表达阳性率则显著低于无浸润和无淋巴结转移者（P〈0．05）。SLeX表达与p16表达呈显著负相关（P〈0．05）。结论SLeX和p16表达与PTC侵袭转移密切相关，联合检测可作为判断PTC预后的参考指标。Objective To investigate the correlation of expression of SLeX and p16 gene protein with the potential of invasion and metastasis in papillary thyroid carcinoma（PTC）. Methods The expression of SLeX and p16 gene protein in 69 cases of PTC were studied by microwave-labelled strept-avidin biotin immunohistochemical method. Results The positive rates of SLeX and p16 in PTC were 69.6% and 58.0% respectively. The positive rate of SLeX expression in the patients with tumor invasion and lymphatic metastasis was significantly higher than that without tumor invasion and lymphatic metastasis （P 〈 0. 05 ）. But the positive rate of p16 expression in the patients with tumor invasion and lymphatic metastasis was significantly lower than that without tumor invasion and lymphatic metastasis （P 〈0. 05 ）. There was a negative correlation between SLeX and p16 expression in PTC （P 〈 O. 05）. Conclusions Expression of SLeX and p16 protein were closely correlated with the invasive and metastasic potential in PTC. SLeX and p16 could be considered as prognostic indications for PTC.

关 键 词：甲状腺肿瘤 SLEX P16 转移 

分 类 号：R73[医药卫生—肿瘤]