纯钛杯在引导骨再生动物实验中的应用研究  

Application of Titanium Cylinder in the Animal Experiment of Guided Bone Regeneration

作　　者：郭毅[1] 周磊[1] 谢建雅[1] 

机构地区：[1]广东省口腔医院.南方医科大学附属口腔医院种植科,广东广州510280

出　　处：《口腔颌面外科杂志》2009年第3期169-171,共3页Journal of Oral and Maxillofacial Surgery

基　　金：国家"十一五"科技支撑计划(2007BAI18BO6);广东省科技三项经费计划项目(2006B19901006)

摘　　要：目的:探讨纯钛杯的制备方法以及在引导骨再生动物实验中的作用与优点。方法:制备钛杯,按分组装入不同骨代用品后定植于兔颅顶骨,术后2、4、6周取样,组织学切片观察。结果:钛杯提供了一个良好的引导骨再生屏障及环境,在显微镜下骨粉与新生骨有良好的分界,可以清晰观察到新生骨高度及密度,并可作量化对照分析。结论:钛杯的应用使引导骨再生动物实验更具可靠性、可比性,操作更为简便,可广泛应用于骨代用品动物实验研究并起到重要作用。Objective： To evaluate the forte of pure titanium cylinder in the guided bone regeneration （GBR） through animal researches. Methods： Titanium cylinders were made by the machine. Then titanium cylinders filled with bone grafts were fixed in the rabbit skull by surgery. After 2, 4, 6 weeks, the animals were sacrificed to obtain sections for histological and histomorphomlogical examination. Results： The titanium cylinder provided a barrier for bone formation.The artificial bone substitutes and new bones were easily distinguished under the microscope. The height and density of new bone were analysed. Conclusion： The application of titanium cylinder can make the GBR animal experiment more reliable, more feasible and easier.

关 键 词：骨代用品 引导骨再生 动物实验 屏障 

分 类 号：R78[医药卫生—口腔医学]