轻度认知功能障碍病人嗅觉功能减退的临床研究  

CLINICAL STUDY OF OLFACTORY DYSFUNCTION IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT

作　　者：兰希福[1] 周永红[1] 张美增[2] 谭莉丽[1] 吴红玉[1] 

机构地区：[1]青岛大学医学院,山东青岛260021 [2]青岛大学医学院附属医院神经内科

出　　处：《青岛大学医学院学报》2009年第5期459-461,464,共4页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨轻度认知功能障碍（MCI）病人嗅觉功能与健康老年人之间的差异以及嗅觉功能与神经心理学的相关性。方法分别对52例MCI病人与40例健康对照组进行简明精神状态量表（MMSE）、蒙特利尔认知测验（MoCA）、社会功能调查表（FAQ）等神经心理学评估以及史尼芬嗅觉棒筛查测验（SSST）等嗅觉功能评估。结果MCI组MMSE、MoCA、FAQ及SSST评分与健康对照组比较,差异均有极显著意义（t=11.73-18.42,P〈0.001）。MCI组嗅觉功能与神经心理学评分呈显著相关性（r=0.705、0.559、-0.659,P〈0.001）,而健康对照组无明显相关性（P〉0.05）。结论MCI是阿尔茨海默病的危险因素,嗅觉功能测试可能是MCI诊断的敏感指标,早期发现和早期干预能够延迟或阻止痴呆的发生、发展。Objective To explore the differences in olfactory function between patients with mild cognitive impairment （MCI） and healthy elderly as well as the correlation of olfactory function and neuropsychology. Methods Neuropsychological test and Sniffin＇ Sticks Screening Test （SSST） such as Mini Mental State Examination （MMSE）, Montreal Cognitive Assessment （MoCA）, and Functional Activities Questionnaire （FAQ） were applied to assess the olfactory function in 52 MCI patients and 40 healthy controls. Results The differences of MMSE, MoCA, FAQ, and SSST between MCI patients and healthy controls were significant （t=11.73-18.42, P〈0.001）. SSST score in MCI was significantly correlated with neuropsychological score （r=0.705,0. 559,-0. 659;P〈0. 001）, hut no significant correlation of above items was noted in the healthy controls （P〉0.05）. Conclusion MCI is a risk factor of Alzheimer disease （AD）. Olfactory screening test may be a sensitive indicator in the diagnosis of MCI. Early detection and early intervention can delay or prevent the occurrence and development of dementia.

关 键 词：认知障碍 阿尔茨海默病 嗅觉障碍 神经心理学 

分 类 号：R749.1[医药卫生—神经病学与精神病学]