胃癌组织Survivin和VEGF-C的表达及意义  

EXPRESSION OF Survivin AND VEGF-C IN GASTRlC CARCINOMA AND ITS SIGNIFICANCE

作　　者：赵光兵[1] 宋修岐[1] 孙少杰[1] 

机构地区：[1]青岛大学医学院第二附属医院普外科,山东青岛266042

出　　处：《青岛大学医学院学报》2009年第5期465-467,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的研究Survivin及血管内皮生长因子C（VEGF-C）在胃癌组织中的表达及临床意义。方法采用免疫组织化学方法检测62例胃癌及20例正常胃黏膜组织中Survivin及VEGF-C的表达,并分析其与肿瘤组织学类型、临床分期、浸润深度和淋巴结转移的关系。结果Survivin和VEGF-C在胃癌组织中阳性表达率分别为69.4%（43/62）和75.8%（47/62）,在正常胃黏膜组织中表达的阳性率为10.0%（2/20）和20.0%（4/20）,两组比较差异有显著性（χ2=21.50、20.02,P〈0.05）。胃癌组织中Survivin及VEGF-C的表达与肿瘤临床分期、浸润深度、细胞分化和有无淋巴结转移密切相关（χ2=4.30~11.13,P〈0.05）。结论Survivin与VEGF-C共同参与了胃癌的发生、发展过程,检测其表达可作为判断胃癌预后的客观指标。Objective To investigate the expression of Survivin and vascular endothelial growth factor C （VEGF-C） in gastric carcinoma and its clinical significance. Methods Immunohistochemical technique was used to determine the expression of Survivin and VEGF C protein in 62 patients with gastric carcinoma and 20 specimens of normal gastric tissue. The relationship between the gene expression and histology type, TNM stage, depth of infiltration, and lymph node metastasis was analyzed. Results The positive expression of Survivin and VEGF C in gastric carcinoma was 69.4% （43/62） and 75.8% （47/62）, respective ly. In normal gastric tissue, the expression of Survivin and VEGF-C was 10.0%（2/20） and 20.0%（4/20）. The difference between the two groups was significant （χ2=21.50, 20.02;P〈0.05）. In the cancer tissue, the expression of Survivin and VEGF C was closely related to TNM stage, depth of invasion, cell differentiation and lymph node metastasis （χ2=4.30-11.13 ,P〈0.05）. Conclusion Both survivin and VEGF C involve in occurrence and development of gastric carcinoma, a detection of the expression may be used as an objective index for predicting the prognosis of this disease.

关 键 词：胃肿瘤 基因 Survivin 血管内皮生长因子C 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]