乳腺浸润性导管癌免疫表型分化规律及临床意义  

Clinical significance and rule of phenotypic differentiation in invasive ductal carcinoma

作　　者：李传伟[1] 龙跃洲[1] 柳雅玲[1] 范姝君[2] 王波[2] 李连宏[2] 

机构地区：[1]泰山医学院病理学教研室,山东泰安271000 [2]大连医科大学病理学教研室

出　　处：《中国妇幼保健》2009年第19期2702-2705,共4页Maternal and Child Health Care of China

基　　金：辽宁省科学技术基金资助〔20042136〕

摘　　要：目的:探讨乳腺癌免疫表型分化规律及临床意义。方法:采用免疫组化SP法检测CK5、CK8及P63在136例乳腺浸润性导管癌中的表达,分析乳腺癌免疫表型分化规律及其与临床病理特征的关系。结果:CK5在乳腺浸润性导管癌中表达较弱,CK8在乳腺浸润性导管癌表达较强;109例(80.15%)乳腺浸润性导管癌呈现CK5-/CK8+腺腔表型,9例(6.62%)呈现CK5+/CK8-干细胞表型,15例(11.03%)呈现CK5+/CK8+混合表型,3例(2.21%)呈现CK5-/CK8-表型,且这种表达与患者的年龄、肿瘤分化程度、淋巴结转移以及临床分期相关;P63在乳腺浸润性导管癌中有11例(8.81%)呈现少量的肿瘤细胞阳性,并且主要表达于低分化的乳腺癌中。结论:CK5+/CK8+、CK5+/CK8-或P63+表型乳腺癌恶性程度高、预后差,免疫表型可作为评价预后的生物学指标。Objective： To explore the clinical significance and rule of phenotypie differentiation in invasive ductal carcinoma. Methods： The expression levels of CK5, CK8 and P63 in 136 case with invasive ductal carcinoma were detected by immunohistochemical staining, the relationship between phenotypic differentiation and clinical -pathological characteristics was analysed. Results： The expression of CK5 was low in invasive ductal carcinoma, while the expression of CK8 was high. 109 cases （80. 15% ） showed CK5^-/CK8^ ＋ phenotype, 9 cases （6. 62% ） showed CK5^＋/CK8^- phenotype, 15 cases （ 11.03% ） showed CK5^＋/CK8^＋ phenotype and 3 cases （2. 21% ） showed CK5^ -/CK8^- phenotype, which was related to patients＇age, tumor differentiation level, lymph node metastasis and clinical staging. The expression of P63 in invasive ductal carcinoma was low, 11 cases （8.81%） showed rare neoplastic cells positive. Conclusion ： CK5^＋/CK8^＋ , CK5^＋/CK8^- or P63^＋ phenotypes breast cancer is high malignant, bad prognosis, and the phenotype might be a novel moleeular marker to predicate the progression of invasive dactal carcinoma.

关 键 词：乳腺浸润性导管癌 CK5 CK8 P63 干细胞 

分 类 号：R737.9[医药卫生—肿瘤]