宫颈癌新辅助化疗的临床初步观察  

Clinical observation of effect of new adjuvant chemotherapy on cervical carcinoma

作　　者：何超蔓[1] 陈曼玲[1] 黎明鸾[1] 胡春霞[1] 吴小妹[1] 卢斋[1] 金松[1] 

机构地区：[1]海南医学院附属医院妇产科,海南海口570102

出　　处：《海南医学院学报》2009年第7期764-766,共3页Journal of Hainan Medical University

基　　金：海南省自然科学基金资助项目(No.806124)~~

摘　　要：目的:探讨新辅助化疗(NACT)对提高宫颈癌临床治疗效果的意义。方法:收集2006年8月～2009年1月住院的Ⅰb～Ⅱb期宫颈癌患者22例,采用2个疗程的静脉化疗之后,14例行宫颈癌根治术,8例Ⅱb期患者行放疗。并观察化疗临床症状缓解情况、肿瘤大小的变化、化疗的毒副反应以及术后病理检查情况。结果:(1)临床症状缓解情况:22例中完全缓解14例(63.64%),明显缓解4例(18.18%),中度缓解4例(18.18%);(2)肿瘤消退情况:完全缓解(CR)3例(13.64%),部分缓解(PR)9例(40.91%),好转(MR)5例(22.73%),稳定(SD)5例(22.73%)。结论:宫颈癌新辅助化疗是安全有效的,缩小了局部病灶,提高了手术切除率。Objective： To study the clinical effects of new adjuvant chemotherapy （NACT） on cervical carcinoma. Methods ： Retrospectively analyzed clinical data of 22 cases with cervical cancer at Ⅰ b-Ⅱ b stage during 2006.8-2009. 1. All cases were treated by intravenous chemotherapy for 2 courses including 14 cases with radical hysterectomy and 8 cases at Ⅱ b stage with radiotherapy. Observed status of clinical symptoms, size of tumor, side effect of chemotherapy and postoperative pathological analysis. Results： 14 out of 22 cases were relieved completely （63.64%） , 4 cases were obviously alleviated （ 18. 18% ） , and 4 cases were relieved moderately （ 18. 18% ）. 3 cases were complete effective （ 13.64% ）, 9 cases were partial effective （40.91%）, and 5 cases were improved （22.73%）, cases were stable diseases with efficacy rate as 77.27% （17/22）. Conclusion： NACT is save and effective, It can reduce local disease focus and increase the resection rate.

关 键 词：宫颈癌 新辅助化疗 手术治疗 

分 类 号：R737.33[医药卫生—肿瘤] R730.53[医药卫生—临床医学]