维甲酸对人早幼粒白血病细胞株CD44、CD54表达的影响  

THE EFFECT OF ALL-TRANS RETINOIC ACID ON NB_4 CELLS CD44 AND CD54 EXPRESSION

作　　者：王秦[1] 景莉[2] 李晓明[2] 叶云[1] 

机构地区：[1]泸州医学院附属医院药剂科,四川泸州646000 [2]泸州医学院附属医院风湿血液科,四川泸州646000

出　　处：《泸州医学院学报》2009年第3期225-227,共3页Journal of Luzhou Medical College

摘　　要：目的:探讨全反式维甲酸(ATRA)对人早幼粒白血病细胞株(NB4)粘附分子CD44、CD54表达的影响。方法:流式细胞术检测0.5μg/mlATRA作用于NB4细胞株24h、72h、120h后CD44、CD54平均荧光强度的变化。结果:ATRA处理NB4细胞株后CD44表达减弱、CD54表达增强,呈时间依赖性(P<0.05)。结论:ATRA能减弱NB4细胞株CD44表达、增强CD54表达。Objective： To investigate the expression of CD44 and （CD54） in NB4 cells under the action of alltrans retinoic acid （ATRA）. Methods ： The expression of CD44 and CD54 induced by ATRA were measured by flow eytometry （FCM）. Results： FCM analysis showed that the CD54 expression increased and the CD44 expression decreased （P〈0.05）. Conclusion： ATRA significantly enhanced CD54 expression and inhibited CD44 expression of NB4 cells.

关 键 词：ATRA 粘附分子 CD44 CD54 

分 类 号：R973[医药卫生—药品]