尿氨基末端肽在转移性骨肿瘤诊断中的意义  

Diagnostic value of urinary NTX in patients with bone metastasis

作　　者：王玲[1] 王宏[2] 邱阳[3] 

机构地区：[1]大连医科大学附属第一医院肿瘤科,辽宁大连116011 [2]大连医科大学附属第一医院骨科,辽宁大连116011 [3]大连医科大学附属第一医院中心实验室,辽宁大连116011

出　　处：《中国实验诊断学》2009年第6期759-760,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨溶骨性骨代谢生化指标尿Ⅰ型胶原交联氨基末端肽(uNTX)检测在恶性肿瘤骨转移诊断中的价值。方法对24例骨转移患者及34例无骨转移的患者,利用ELISA方法测定uNTX水平。结果骨转移组患者uN-TX明显高于无骨转移组(P<0.01),多发转移组明显高于单发骨转移组(P<0.01)。结论uNTX检测可作为恶性肿瘤患者骨转移辅助检查手段。Objective To search the diagnostic evaluation of urinary pyridinoline cross-linked N-telopepfides of type I collagen （uNIX） in patients with bone metastasis. Methods The levels of uNTX of patients with or without bone metastasis were measured using ELISA. Results The uNTX level in patients with bone metastasis was significantly higher than in the patients without bone metastasis （ P 〈 0.01 ） ;the uNTX level in patients with multiple bone metastasis was significantly higher than in the patients with single bone metastasis （ P 〈 0.01 ） . Conclusion The measurement of uNTX can be used as a diagnostic examination for bone metastasis.

关 键 词：尿氨基末端肽 骨转移 诊断 

分 类 号：R738.1[医药卫生—肿瘤]