^(18)F-FDG SPECT/CT同机融合显像在原发灶不明转移癌中的临床应用  

Clinical application of the ^(18)F-FDG SPECT/CT fusion imaging in detecting carcinoma of unknown primary site

作　　者：林小敏[1] 蔡志华[1] 唐明灯[1] 倪雷春[1] 林端瑜[1] 

机构地区：[1]福建省肿瘤医院核医学科,350014

出　　处：《福建医药杂志》2009年第3期106-108,共3页Fujian Medical Journal

摘　　要：目的探讨18F-FDG SPECT/CT同机融合显像在原发灶不明转移癌中的应用价值。方法对51例行18F-FDG SPECT/CT同机融合显像,同时获得SPECT、CT及两者的融合图像,至少由2名核医学科主治以上医师对图像进行双盲阅片诊断,结果与病理或随访结论相比较。结果18F-FDG SPECT/CT融合显像、单独SPECT显像及单独CT显像对原发灶的检出率分别为43.13%(22/51)、31.37%(16/51)、21.57%(11/51),差别有统计学意义(P<0.05)。18F-FDG SPECT/CT同机融合显像灵敏度为88.00%,特异性为84.62%,准确度为86.27%,阳性预测值为84.62%,阴性预测值为88.00%。经SPECT/CT同机融合显像检查后32例原发灶不明转移癌的临床治疗方案得以确定或调整,其中10例临床分期得以提高。结论18F-FDG SPECT/CT同机融合显像对原发不明转移癌的诊断、再分期和治疗有重要临床价值。Objective To investigate the role of ^18F-FDG SPECT/CT fusion imaging in detecting carcinoma of unknown primary site （CUP）. Methods Fifty-one with CUP syndrome were examined by the ^18F-FDG SPECT/CT fusion imaging. The images of SPECT alone, CT alone and SPECT/CT were blindly interpreted by more than two experienced nuclear medicine specialist. The results of images were compared to the conclusion of pathology or follow-up. Results The detection rate of SPECT/CT fusion imaging （43.13%, 22/51） was higher than that of SPECT alone （31.37%, 16/51） and CT alone （21.57%, 11/51） . The difference among them was statically significant （P〈0.05）. The sensitivety, speciality, accuracy, positive predictive value, negative predictive value of the SPECT/CT fusion imaging were 88.00%, 84.62%, 86.27%, 84.62% and 88.00% respectively. After the examination of ^18F-FDG SPECT/CT fusion imaging, the clinical treatment of 32 CUPs was decided or changed, among of which 10 CUPs clinic stages were evaluated. Conclusion ^18F-FDG SPECT/CT fusion imaging may play an important role in detection, therapy and restaging of CUP.

关 键 词：SPECT/CT融合显像 原发灶 转移癌 脱氧葡萄糖 

分 类 号：R730.4[医药卫生—肿瘤]