转化生长因子-β1的表达与斑秃发病关系的研究  

Relationship between cytokine transforming growth factor-β1 and alopecia areata

作　　者：黄卫宁[1] 黄卓辉[1] 侯显曾[1] 卢浩锵[1] 徐霞[2] 

机构地区：[1]广州医学院第一附属医院皮肤科,广州510120 [2]广州医学院第一附属医院检验系,广州510120

出　　处：《华中医学杂志》2009年第3期120-121,125,共3页Central China Medical Journal

基　　金：广东省医学科学技术基金(广东省卫生厅资助项目)(No.A2005293)

摘　　要：目的观察转化生长因子-β1(TGF-β1)表达水平与斑秃发病的关系,探讨斑秃病情的检测和疗效的观察指标。方法应用酶标法检测斑秃患者血清中细胞因子TGF-β1的表达水平。结果重型斑秃、轻型斑秃的血清TGF-β1水平明显低于正常对照组(P<0.01),且重型斑秃低于轻型斑秃患者(P<0.05)。血清TGF-β1浓度与病情严重程度呈高度正相关(r=0.841,P<0.01)。结论TGF-β1因子与斑秃的病情相关,可用于临床病情与疗效的监测。Objective To study the relationship between the expression of transforming growth factor--β1 （TGF--β1） and alopecia areata （AA）, and explore the indexes for monitorying illness conditions and curative effectiveness. Methods The serum level of TGF-β1 was determined by enzyme-linked immunoabsorbent assays （ELISA）. Results The serum levels of TGF-β1 in AA patients were lower than those in controls （P〈0. 01 ）, and those in severe AA patients were significantly lower than in localized AA （P〈0. 05）. Correlation analysis revealed there was a markedly correlation between TGF-β1 levels and illness condition （r = 0. 845, P〈0. 01）. Conclusion TGF-β1 is relevant to the illness condition and could be useful in monitoring the illness condition and curative effectiveness.

关 键 词：斑秃 细胞因子 转化生长因子-Β1 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]