创伤后应激障碍患者的焦虑抑郁与血浆皮质醇水平观察  

An observation on changes of anxiety-depression symptoms and level of serium cortisone in patients with post-traumatic stress disorder

作　　者：周涵辉[1] 高镇松[2] 钟湧江 

机构地区：[1]汕头大学精神卫生中心,广东515063 [2]广东省汕头市第四人民医院 [3]广东省揭阳市东山区第一人民医院

出　　处：《精神医学杂志》2009年第3期201-202,共2页Journal of Psychiatry

摘　　要：目的观察创伤后应激障碍(PTSD)患者的焦虑抑郁症状与血浆皮质醇水平的变化。方法以PTSD患者31例为研究组,应用抑郁自评量表(SDS)和焦虑自评量表(SAS)为工具,于入院后0周、1周末和4周末分别评定患者的抑郁焦虑症状,并同步测定血浆皮质醇水平,观察其抑郁焦虑程度及血浆皮质醇水平的变化,并与30名健康者作对照。结果研究组的SDS、SAS总分在发病期(0周和1周末)均显著升高(P<0.01),好转后恢复至正常水平。与对照组比较,研究组的血浆皮质醇水平在发病期显著升高(P<0.01),随着创伤程度的减轻而恢复正常。研究组血浆皮质醇水平的变化(0周与1周末,1周末与4周末)与SDS、SAS总分的变化无相关性(P>0.05)。结论PTSD患者在发病期存在不同程度的焦虑抑郁情绪,伴血浆皮质醇水平升高,此期需给予相应的药物治疗和心理干预。Objective To observe changes of anxiety-depression symptoms and level of serium cortisone in patients with Post-traumatic Stress Disorder （PTSD）. Methods A total of 31 patients with PTSD for study group were evaluated with Self-rating Depression Scale （SDS） and Self-rating Anxiety Scale （SAS） before treatment,and at the end of 1st,4th week after treatment. The levels of serium cortisone were tested,compared with 30 normal controls. Results In study group,the scores of SDS and SAS were significantly higher during onset period （P〈0.01） and decreased to normal level after recovery. Compared with control group,the serium cortisone of patients with PTSD significantly increased during onset period （P〈0. 01） and recovered with anxiety-depression symptoms＇ improvement. There had no significant correlation between the changes of serium cortisone and the changes of total scores of SDS and SAS in study group （P〉0.05）. Conclusion During onset period, patients with PTSD have some extent anxiety-depression symptoms with higher level of serium cortisone. Drug-treatment and psychological interventions are needed.

关 键 词：创伤后应激障碍 焦虑 抑郁 血浆皮质醇 

分 类 号：R749.7[医药卫生—神经病学与精神病学]