δ-ALA-PDT治疗面部基底细胞癌、Bowen病及日光性角化病的临床研究  

The clinical research on treating facial basal cell carcinoma,Bowen's disease and actinic keratosis with δ-Aminolaevulinic acid-photodynamic therapy

作　　者：李洁思 李森真 李春香 

机构地区：[1]广东省汕头市皮肤性病防治院,汕头515041

出　　处：《白求恩军医学院学报》2009年第3期145-146,共2页Journal of Bethune Military Medical College

摘　　要：目的探讨δ-氨基酮戊酸光动力学疗法(δ-ALA-PDT)治疗面部浅表基底细胞癌(BCC)、Bowen病(BD)及日光性角化病(AK)的近期效果。方法24例患者中,16例皮肤BCC,3例BD病,5例AK,均经病理组织学确诊。局部外用新鲜配制的20%ALA乳膏,封包4 h后用中心波长630 nm的德国Waldmann PDT1200不连续红光照射,病变部位照射强度为105～168 mW/cm2,剂量为150～200 J/cm2,照射时间20～30 min。结果经过1次(12例)、2次(3例)和3次(1例)治疗后,BCC患者10例完全缓解,5例部分缓解,1例无反应;BD患者2例完全缓解,1例部分缓解;AK患者3例完全缓解,2例部分缓解。结论δ-ALA-PDT治疗面部浅表BCC、BD病及AK有效,方法简单,患者耐受性好,无瘢痕形成,在保持患者面部美容方面有优势。Objective To investigate the effects of δ-Aminolaevulinic acid-photodynamic therapy（ δ-ALA-PDT） on facial basal cell carcinoma（BCC） , Bowen＇ s disease （BD） , actinic keratosis （ AK ）. Methods Among 24 patients, 16 patients suffering from BCC ,3 patients from BD and 5 patients from AK were confirmed by histopathological examination of biopsy. All of the patients were given topical 20% ALA cream which was prepared freshly and under occlusive dressing for 4h. Light at 630 nm was obtained from the Waldmann PDT 1200 and its output was set at 105 - 168 mW/cm^2. Incident light doses of 150 - 200 J/cm^2 were applied. The exposure time was 20 - 30 min. Results Treated by once （ 12 patients） , twice （3 patients） and 3 times（ 1 patient） of δ-ALA -PDT,of all the patients with BCC,IO patients were cured,5 patients had partial remission and 1 patient was invalid to the treatment ;of all the patients with BD,2 patients was cured, 1 patient had partial remission and 1 patient completely relieve from the disease;of all the patients with AK ,3 patients were cured and 2 patients had partial remission. Conclusion δ-ALA-PDT is an effective, simple and well-tolerated treatment for BCC, BD and AK. It hasn＇ t cicatrisation and has its advantage in keeping the prosopo-cosmetology of the patients.

关 键 词：Δ-氨基酮戊酸 光动力学疗法 基底细胞癌 BOWEN病 日光性角化病 

分 类 号：R739.5[医药卫生—肿瘤]