体部伽玛刀配合肝外胆管引流治疗恶性梗阻性黄疸的临床分析  

Clinical analysis of body gama-knife combined with percutaneous transhpatic cholangiography and drainage in treatment of malignant obstructive jaundice

作　　者：董桂云 叶斌[2] 虞喜豪 肖作平 王咏梅 

机构地区：[1]解放军八五医院伽玛刀病房,200032 [2]上海应用技术学院,200235 [3]解放军八五医院介入科,200032

出　　处：《中国老年保健医学》2009年第2期106-107,共2页Chinese Journal of Geriatric Care

摘　　要：目的探讨体部伽玛刀配合肝外胆管引流治疗恶性肿瘤所致黄疸的临床意义。方法58例恶性肿瘤合并梗阻性黄疸患者,均实行体部伽玛刀治疗。其中28例在行伽玛刀治疗前行肝外胆管引流,8例在行伽玛刀治疗期间因黄疸加重,暂停伽玛刀治疗,行肝外胆管引流,黄疸减轻后继续完成伽玛刀治疗,22例在行伽玛刀治疗后半年内黄疸进行性升高,给予行肝外胆管引流。按照RECIST标准评价近期疗效,参照Karnofsky评分,(KPS)变化评价生活质量。2周期后评价疗效。主要终点指标为疾病进展时间(TTP)和总生存期(OS),次要终点为客观有效率(RR)、生活质量和安全性。结果患者在进行伽玛刀治疗及肝外引流治疗后半年内复查黄疸消退,未复发。延长患者生存期。结论短期结果显示,恶性肿瘤所致梗阻性黄疸,经伽玛刀治疗配合肝外胆管引流,明显提高了患者的生活质量,疗效可靠,延长患者的TTP。Objective To Evaluate the clinical implication of Stereotatic Radiation Therapy （SRT） combination with PTCD in jaundice. Methods We performed 58 patients with Jaundice,treated with Body Gamma Knife and PTCD. Result The remission rate of jaundice was 98.2% ,The effctiveness was better. The survival quality of patients was improved signifi canfly. Conclusion PTCD add Body-Gamma Knife treatment can raise the local control rate of Malignant Turner Jaundice, and strengthen organism immunity function.Prolong the TIP of the patient.

关 键 词：伽玛刀 肝外胆管引流 恶性肿瘤黄疸 

分 类 号：R730.5[医药卫生—肿瘤]