口腔扁平苔藓局部淋巴细胞增殖细胞核抗原、Bcl-2、Bax的表达  

Expressions of proliferating cell nuclear antigen,Bcl-2,and Bax in lymphocytes of patients with oral lichen planus

作　　者：雷蕾[1] 谭为霞[1] 于淼[1] 周序珑 

机构地区：[1]暨南大学医学院口腔医学系,广东广州510632 [2]暨南大学医学院病理教研室,广东广州510632

出　　处：《南方医科大学学报》2009年第5期946-948,共3页Journal of Southern Medical University

基　　金：广东省自然科学基金(8151063201000065)

摘　　要：目的研究增殖细胞核抗原(PCNA)、Bcl-2、Bax在口腔扁平苔藓(OLP)淋巴细胞中的表达以及与OLP慢性炎症长期迁延的关系。方法采用免疫组化法半定量检测OLP组织和正常口腔粘膜组织中PCNA、Bcl-2和Bax的蛋白表达。结果OLP组淋巴细胞与正常组相比,PCNA、Bcl-2蛋白表达增强,而Bax无明显变化。在普通型和充血糜烂型OLP中,无论是PCNA还是Bcl-2,表达均无显著性的差异。结论PCNA在OLP病损局部淋巴细胞中表达增强,Bcl-2/Bax表达不平衡,提示可能存在增殖活跃及凋亡障碍。这可能是OLP淋巴细胞持续浸润、局部炎症迁延的重要原因。Objective To investigate the expressions of proliferating cell nuclear antigen （PCNA）, B cell lymphoma-2 （Bcl-2） and Bcl-associated X （Bax） in the lymphocytes of patients with oral lichen planus （OLP）. Methods Immunohistochemistry was used for detecting the expressions ofPCNA, Bcl-2 and Bax proteins in oral lichen planus tissue and normol oral mucosa （NOM）. Results The expressions of PCNA and Bcl-2 proteins increased significantly in the lymphocytes of patients with OLP compared with those in NOM. The expressions of PCNA and Bcl-2 proteins showed no significant differences between patients with OLP of general type and erosive type. Conclusion Increased expression of PCNA and the imbalance of Bcl-2/Bax expressions in the lymphocytes of patients with OLP can be important causes for continuous lymphocyte infiltration in OLP.

关 键 词：口腔扁平苔藓 淋巴细胞 PCNA BCL-2 BAX 

分 类 号：R781.5[医药卫生—口腔医学]