对甲苯磺酰胺瘤内注射结合放疗及化疗治疗裸鼠移植性肝癌的实验观察  

Terapeutic effect of para-toluenesulfonamide on transplanted hepatocarcinoma in nude mice

作　　者：孟辉[1] 李民英[1] 朱伟良[1] 张积仁[1] 

机构地区：[1]南方医科大学珠江医院肿瘤中心,广东广州510282

出　　处：《南方医科大学学报》2009年第5期1024-1025,共2页Journal of Southern Medical University

摘　　要：目的观察放疗及化疗结合对甲苯磺酰胺(PTS)瘤内局部注射对裸鼠移植性肝癌的治疗作用,为临床应用提供实验依据。方法制作裸鼠皮下移植性肿瘤模型,将60只Balb/c(nu/nu)裸鼠随机分为6组,即PTS组、放疗组、放疗+PTS组、化疗组、化疗+PTS组和对照组,分别经皮瘤内注射PTS、局部肿瘤单纯放疗、瘤内注射PTS+局部肿瘤放疗、局部肿瘤经尾静脉注射丝裂霉素化疗、瘤内注射PTS+局部肿瘤经尾静脉注射丝裂霉素化疗、生理盐水,观察各组抑瘤率和生存期。结果(1)放疗、化疗、PTS和放疗、化疗分别结合PTS局部肿瘤注射明显抑制肿瘤生长,而放疗、化疗结合局部肿瘤注射PTS抑制肿瘤生长又优于单纯化疗,与单纯放疗相比无统计学意义;(2)放疗、化疗、PTS和放疗、化疗分别结合PTS局部肿瘤注射裸鼠生存时间无统计学差别。结论放疗、化疗结合局部肿瘤注射PTS治疗裸鼠移植性肝癌,疗效优于单纯放疗或单纯化疗。Objective To study the effect of of percutaneous para-toluenesulfonamide （PTS） injection on transplanted hepatocarcinoma in nude mice. Methods Sixty nude mice with subcutaneous transplanted hepatocareinoma were randomized into 6 groups, namely PTS, chemotherapy, radiotherapy, PTS＋chemotherapy, PTS＋radiotherapy and control groups. PTS were injected into the tumor in the nude mouse models as indicated, and the tumor growth rate and survival time of the mice were recorded. Results All the treatments resulted in effective arrest of the tumor growth, but the effects of PTS＋chemotherapy and PTS＋radiotherapy were more obvious. No significant difference in the survival time of the mice were noted between the groups. Conclusion PTS＋chemotherapy and PTS＋radiotherapy are safe and reliable, and produces better effects than either radiotherapy or chemotherapy alone.

关 键 词：肝肿瘤 对甲苯磺酰胺 丝裂霉素 放射治疗 联合治疗 

分 类 号：R735.7[医药卫生—肿瘤]