髂内动脉化疗栓塞药泵置入联合手术治疗浸润性膀胱癌  

Internal iliac artery chemotherapy plus embolization and infusion pump chemotherapy combined with surgical operation for the treatment of invasive bladder cancer

作　　者：许彪[1] 文斌[1] 刘惕生[1] 韦力谦[1] 

机构地区：[1]广西医科大学第5附属医院放射科介入室,广西柳州545001

出　　处：《医学影像学杂志》2009年第6期716-719,共4页Journal of Medical Imaging

基　　金：广西卫生厅医药卫生科研课题(编号;22001080)

摘　　要：目的:探讨治疗浸润性膀胱癌的有效方法。方法:对60例经手术、病理证实并获随访的浸润性膀胱癌患者分为A、B两组,A组30例为髂内动脉化疗栓塞药泵置入后手术治疗组,B组30例为单纯手术治疗组,分析比较两组患者术后复发率、病死率的差异,了解介入联合手术治疗的效应。结果:A组患者术前髂内动脉化疗栓塞后完全缓解率(CR)为16.7%(5/30),部分缓解率(PR)为70%(21/30),有效率(CR+PR)为86.7%。术后切除标本病理检查光镜下可见大片状癌细胞变性坏死,间质见炎细胞浸润。A组死亡4例(13.3%),B组死亡8例(26.7%)。A组复发6例(20%),B组复发14例(46.7%)。结论:髂内动脉化疗栓塞药泵置入后手术治疗浸润性膀胱癌,安全有效,能显著提高膀胱癌的疗效。Objective： To explore the effective therapy for invasive bladder cancer. Methods： Sixty patients with invasive bladder cancer were divided into A group and B group in random sample. Intra-intemal lilac-arterial chemotherapy and infusion pump chemotherapy combined with surgical operation were performed in A group. Surgical operation were simply performed in B group. The difference of the recrudescence rate and sutural rate between two groups were analyzed. The effect of intra-arterial chemotherapy combined with surgical operation at the same time was evaluated. Results：The complete response rate （CR） and the partial response rate （PR） were 16.7% （5/ 30） and 70% （21/30） respectively. Tumor response rate （CR＋ PR） was 86.7%. Pathomorpholoical features, including large palehy necrosis, degeneration, and inflamematory changes of carcinoma tissue, were founded in A group at the same time. In A group, 6 eases relapsed （20%） and 4 cases died （13.3%）. In B group, 14 eases relapsed （46.7%） and 8 eases died （26.7%）. Conelusion：The eombinability of intra-intemal iliac-arterial, infusion pump chemotherapy and surgical operation are safe, effective for invasive bladder cancer. It can improve the sturvive and life quality of patients.

关 键 词：浸润性膀胱癌 髂内动脉化疗 药泵 外科手术 介入放射学 

分 类 号：R737.14[医药卫生—肿瘤] R815[医药卫生—临床医学]