兔VX2肝癌动脉栓塞治疗前后血供变化与病理分析  

The changes in blood supply and pathological findings in VX2 liver tumors of rabbits:before and after treated with transcatheter arterial embolization

作　　者：鲁东[1] 吕维富[1] 高斌[2] 张正峰[1] 张爱武[1] 谢亚敏[1] 李双生[1] 

机构地区：[1]安徽省立医院影像科,安徽合肥230001 [2]合肥市第一人民医院影像科,安徽合肥230061

出　　处：《医学影像学杂志》2009年第6期735-738,共4页Journal of Medical Imaging

基　　金：安徽省高校省级自然科学研究计划重点项目(编号:KJ2008A33ZC)

摘　　要：目的:探讨兔VX2肝癌经导管肝动脉碘化油栓塞术前后的血供变化及病理特征。方法:将36只荷VX2肝癌实验兔随机分为实验组(A组,n=24)、假手术组(B组,n=6)及空白对照组(C组,n=6)。均于接种后第14、15天分别行CT扫描及肝动脉、门静脉DSA检查,A组同时行经导管碘化油栓塞肿瘤供血动脉,C组于DSA后处死。A、B组于第21、22天分别行CT平扫及DSA检查,并于DSA后处死。结果:CT及DSA检查证实35例(97.22%,35/36)为富血供肿瘤,且主要由肝动脉供血,仅1例为门静脉供血。第3周时A、B组DSA均示仍为肝动脉供血,无门静脉供血。栓塞后肿瘤组织主要由凝固性坏死及周边残存癌组织组成。结论:兔VX2肝癌大多数为富血供肿瘤且主要由肝动脉供血。经动脉碘化油栓塞不能完全阻断肿瘤血供,残癌组织仍为肝动脉供血,肝癌组织中的门静脉仅仅是解剖上的血流通过,并不参与肿瘤血供。Objective： To analyse the changes in blood supply and pathological features in VX2 liver tumors of rabbits after treated with transcatheter arterial embolization （TAE）. Methods： 36 rabbits model bearing VX2 liver tumor were selected for experiment and randomly divided into 3 groups： experimental group （group A, n= 24）, pseudo-operative group （group B, n = 6） and control group （group C, n = 6）. The liver cr plain scan and dual-phase dynamic contrast enhanced scan were performed in day 14 after tumor implantation. One day after CT scan, the digital subtraction angiography （DSA） for hepatic artery and portal vein were performed. Group A was embolizated with lipiodol, and group C was killed after DSA to undertaken histopathologie examination. On day 21 and day 22, the remaining models were performed with CT plain scan and DSA examination respectively, then treated as group C. Results：The CT and DSA examination demonstrated that the blood supplies were hypervascular and mainly by the hepatic artery in 35 rabbits （97.22% ,35/36）, only 1 ease was the portal vein. On day 22, the DSA performance was similar to the day 15. The tumor was mainly composed by coagulability necrosis and the peripheral survival cancerous tissue after TAE. Condttsion： The majority of VX2 liver tumors of rabbits was hypervascnlar, which supplied mainly by the hepatic artery. TAE with lipiodol can not completely block the tumor blood supply, it was still from the hepatic artery in the survival cancerous tissue, not from portal vein. The portal vein within tomur was merely flowed through in the anatomy, which did not involved in tumor blood supplying.

关 键 词：VX2肝癌 放射学 介入性 栓塞 治疗性 动物 实验研究 

分 类 号：R735.7[医药卫生—肿瘤] R815[医药卫生—临床医学]