膀胱尿路上皮癌患者外周血T淋巴细胞凋亡蛋白Fas的表达  

Expression of Fas in peripheral blood T lymphocytes in patients with bladder urothelial carcinoma

作　　者：罗广承[1] 刘莉莉[2] 白培明[1] 张楠根[1] 颜志坚[1] 

机构地区：[1]厦门大学附属中山医院泌尿外科福建医科大学教学医院,361004 [2]厦门大学附属中山医院检验中心福建医科大学教学医院,361004

出　　处：《中华实验外科杂志》2009年第7期920-921,共2页Chinese Journal of Experimental Surgery

摘　　要：目的探讨膀胱尿路上皮癌与Fas介导的血T淋巴细胞凋亡的关系。方法应用流式细胞仪检测52例膀胱癌患者和37例健康对照者外周血CD4Fas、CD8Fas阳性T细胞。结果膀胱癌患者外周血CD4、CD8Fas阳性T细胞分别为（20．74±9．02）％、（7．51±5．93）％，对照组分别为（15．68±5．58）％、（4．27±3．08）％，肿瘤组较对照组明显增加（P〈0．01）。浸润组CD8Fas阳性T细胞数为（5．83±3．95）％，表浅组为（5．83±3．95）％，浸润组较表浅组明显降低（P〈0．05）。复发组CD4、CD8Fas阳性T细胞与初发组比较差异无统计学意义（P〉0．05）。结论血T淋巴细胞Fas表达的异常可能在膀胱癌的发生发展中起重要的作用。Objective To investigate the relationship between the Fas expression in peripheral blood T cells and bladder transitional cell carcinoma （TCC）. Methods The Fas expression in peripheral blood T cells of 52 patients with TCC and 37 healthy people was detected by flowcytometry. The Fas-positive rate was compared by t test between two designed groups. Results The Fas expression in CD4^± [ （20. 74 ± 9. 02）% ] and CD8^±[ （7. 51 ±5. 93 ）% ] was increased in TCC patients as compared with controls （P 〈 0. O1 ）. Fas-positive CD8^± cells were reduced in invasive TCC as compared with superficial TCC [ （ 5.83 ± 3.95 ） % vs （ 5.83 ± 3.95 ） %, P 〈 0. 05 ], but there was no difference between primary and recurrent cases （ P 〉 0. 05 ）. Conclusion The abnormal Fas expression in peripheral blood T cells may play an important role in the development and progression of TCC.

关 键 词：膀胱肿瘤 FAS蛋白 淋巴细胞 脱噬作用 

分 类 号：R737.14[医药卫生—肿瘤] R339.38[医药卫生—临床医学]