非小细胞肺癌组织中p16基因表达的意义  

Expression and Significance of p16 Gene Protein in Non-small Cell Lung Cancer

作　　者：周华富[1] 张兴华[1] 薛邦德[1] 冼磊[1] 何巍[1] 

机构地区：[1]广西医科大学第一附属医院心胸外科,南宁市530021

出　　处：《广西医学》2009年第6期776-778,共3页Guangxi Medical Journal

基　　金：广西科学基金(桂科自0542078)

摘　　要：目的探讨p16基因蛋白在人非小细胞肺癌组织中的表达情况。方法应用免疫组化SP法检测45例非小细胞肺癌组织、21例肺良性疾病组织中p16基因蛋白的表达情况。结果肺良性疾病中p16蛋白阳性率85.7%,高于肺癌组织的51.1%,差异有统计学意义(P=0.004);p16蛋白表达阳性率肺癌Ⅰ、Ⅱ期高于Ⅲ、Ⅳ期,无淋巴结转移者高于有淋巴结转移者(P<0.05)。结论p16基因蛋白的表达情况与非小细胞肺癌的发生、发展有关。Objective To investigate the expression of p16 gene protein in non-small cell lung cancer. Methods With SP immunohistochemistry, tissue of 21 cases of lung benign diseases and 45 of non-small cell lung cancer were stained by using the monoclonal antibody against the human p16 protein. Results Expression of p16 gene protein was observed in 85.7% of normal tissues,while 51.1% of lung cancer tissues showed p16 gene protein expression （P = 0. 004）. The expression of p16 protein positive rate was significantly correlated with the clinical stage （ Ⅰ , Ⅱ stage was higher than Ⅲ, Ⅳ stage） and the lymph node metastasis was lower than the non one （P 〈 0. 05）. Conclusion Expression of p16 protein was related to the carcinogenesis and development of lung cancer.

关 键 词：非小细胞肺癌 免疫组织化学 P16蛋白表达 

分 类 号：R734.2[医药卫生—肿瘤]