白细胞介素-6基因多态性及其与卵巢肿瘤的相关性  

IL-6 gene polymorphism and its relationship with ovarian neoplasms

作　　者：曲爱忠[1] 梁婧[1] 刘晓琳(综述)[1] 李岩(审校)[1] 

机构地区：[1]山东大学山东省千佛山医院肿瘤科,山东济南250012

出　　处：《国际肿瘤学杂志》2009年第6期472-473,共2页Journal of International Oncology

基　　金：山东省科技厅自然基金项目（2005ZX04）

摘　　要：临床研究发现，卵巢肿瘤患者白细胞介素（IL）-6水平明显升高，其升高能促进卵巢肿瘤的发生。IL-6升高可能是由于IL-6基因多态性影响其转录和表达。然而IL-6基因多态性与卵巢肿瘤是否具有相关性，目前尚存争议。Clinical studies find that the level of IL-6 is significantly up-regulated in ovarian neoplasms patients. It can promote the carcinogenesis of ovarian. The up-regulation of IL-6 may be correlated with the IL- 6 gene polymorphism which affects its transcription and expression. However, there is disputation in association between IL-6 gene polymorphism and ovarian neoplasms.

关 键 词：白细胞介素6 多态性 单核苷酸 卵巢肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]