谷氨酰胺对术后早期腹腔化疗的结肠吻合口愈合的影响  

Effect of glutamine on the healing of colon anastomoses during early postoperative intraperitoneal chemo- therapy

作　　者：张松岩[1] 徐海涛[1] 肖敏[1] 黄孙卉[2] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150081 [2]哈尔滨医科大学肿瘤防治研究所

出　　处：《实用肿瘤学杂志》2009年第3期235-237,共3页Practical Oncology Journal

摘　　要：目的研究应用谷氨酰胺（glutamine）对术后早期腹腔化疗条件下结肠吻合口愈合的影响。方法Wistar大鼠60只，随机分为3组：对照组，单纯行肠切除吻合；术后早期腹腔化疗组（5一Fu组），术后连续3天腹腔内注射氟尿嘧啶（5-Fu）（20mg／kg·d）；glutamine组，术后给予谷氨酰胺（1g／kg·d）7天及术后早期腹腔化疗。术后8天处死各组大鼠，剖腹切取吻合口测量吻合口评分（评分越高提示吻合口与周围组织的黏连越重）和测量吻合口破裂压力及进行吻合口组织学评分。结果谷氨酰胺组的吻合口评分2．00，低于对照组（2．60），显著低于5-Fu组的2．90，P〈0．05；差异有统计学意义。谷氨酰胺组的吻合口破裂压力229．95mmHg，高于对照组（199．75mmHg），P〈0．05；显著高于5-Fu组（171．79mm—Hg），P〈0．01。谷氨酰胺组的吻合口组织学评分（2．9），高于对照组（2．1）及5-Fu组（1．7），P〈0．05。结论应用谷氨酰胺能提高吻合口愈合强度，促进术后早期腹腔化疗条件下结肠吻合口愈合。Objective To investigate the effect of glutamine on the healing of colon anastomoses after early postoperative intraperitoneal chemotherapy. Methods Sixty rats were randomized into 3 groups： control group：only colon resection and sutured anastomosis was performed;early postoperative intraperitoneal chemotherapy（EPIC） group ：5 - Fu （20 mg/kg · d） was injected intraperitoneally for 3 days after the operation; glutamine group：the EPIC was given and glutamine（1 g/kg · d）was given from mouth for7 days. All the rats were killed on the 8th postoperative day to investigate the adhesion formation score,the bursting pressure, and the macroscopical examination. Results The adhesion formation score of the early postoperative intraperitoneal chemotherapy group was significantly higer than that of other groups;the bursting pressure of the glutamine group was significantly higer than that of other groups ; There was more fibrobtast activity in the glutamine group than that in other group （P 〈 0.05）. Conclusion Using glutamine can improve the healing of colon anastomoses in the condition of the early postoperative intraperitoneal chemotherapy

关 键 词：腹腔化疗 生长激素 肠吻合 

分 类 号：R735.35[医药卫生—肿瘤]