皖南山区家族性全面性强直-阵挛性发作患儿智商及影响因素  

Intelligence Quotient and Affecting Factors of Children with Familial Generalized Tonic-Clonic Seizure in A Mountain Area of South of Anhui Province

作　　者：张超[1] 黄会芝[1] 李小燕[1] 金岚[1] 吴德[1] 唐久来[1] 

机构地区：[1]安徽医科大学第一附属医院小儿神经康复中心,合肥230022

出　　处：《实用儿科临床杂志》2009年第12期912-914,917,共4页Journal of Applied Clinical Pediatrics

基　　金：安徽省"十五"重大科技专项项目资助(2001303005)

摘　　要：目的分析家族性全面性强直-阵挛性发作(GTCS)患儿和他们同胞的智商(IQ),探讨影响癫患儿IQ的相关因素。方法选择皖南山区20个癫家系中的9～16岁的GTCS患儿28例作为试验组,随机抽选28例与患儿年龄差距最小同胞儿童为对照1组,30例同村的年龄、性别匹配相近的健康儿童为对照2组,比较3组儿童的IQ水平;并记录癫发病的相关资料和影响儿童IQ的因素。结果1.试验组32%儿童IQ在平均水平,21%高于平均水平;与对照1组及对照2组比较均有显著差异(Pa<0.01);2.试验组儿童的总智商较对照1组、对照2组均显著降低(Pa<0.001),除了填图与图片排列外,试验组所有其他分测验得分和2个对照组之间均有显著性差异;3.2个对照组之间的IQ水平及各分测验得分无显著性差异;4.癫患儿IQ与父亲受教育程度、癫发病年龄、癫发作病程、癫发作频率、癫持续状态显著相关(r=0.453,0.506,-0.533,-0.708,-0.732Pa<0.05);5.多元线性逐步回归分析,父亲受教育程度与癫发作病程是影响癫患儿IQ的主要因素。结论家族性GTCS患儿的IQ及各分测验得分明显低于健康儿童;其同胞的IQ水平与健康儿童无统计学差异;癫发作病程、父亲受教育程度是影响患儿IQ最重要的癫因素,其他依次为:癫持续状态、起病年龄、癫发作次数、癫发作频率。Objective To analyze the intelligence quotient （IQ） profile of the children with familial generalized tonic - clonic seizure （GTCS） and their siblings, and explore the factors influencing IQ of children with epilepsy further. Methods Twenty - eight children with GTCS aged 9 - 16 years in 20 epilepsy families in a mountain area of Southern Anhui province were selected as experimental group; 28 healthy siblings of the children were randomly selected as control group 1, who did not have epilepsy and were closest in age to the children with epilepsy; the other healthy 30 children were assigned as control group 2, who had lived in the same village and were gender - age matched with the experimental group. The IQ of the 3 groups of children was compared, and all data of influencing IQ development of children and seizures of children with epilepsy at the same time were recorded. Results 1. In the experimental group,32% children had an average IQ and 21% of children had IQ above the average, which was significantly lower than that in control group 1 and control group 2, there were significant differences（ Pa 〈0.01 ） among 3 groups. 2. The mean Full Scale IQ of children in the experimental group was significantly lower than that control group 1 and control group 2（ Pa 〈0.001 ）. The difference between experimental group and 2 control groups were significant for almost all the subtest quotients except for the completion of drawing and picture arrangement. 3. There were no significant differences between the control group 1 and the control group 2 in the IQ and the subtest quotients. 4. IQ scores of children with epilepsy showed significant correlation with father＇s education, age at onset of epilepsy,duration of seizure disorder, seizure frequency and status epilepticus （ r = 0.453,0. 506, -0. 533, - 0.708, - 0.732 Pa 〈 0.05 ）. 5. The education levels of their fathers and duration of seizure disorder were the main factors affecting IQ of the children with epilepsy by the multiple stepwise regres

关 键 词：特发性全面性癫痫 全面性强直-阵挛性发作 总智商 言语智商 操作智商 

分 类 号：R742.1[医药卫生—神经病学与精神病学]